grant
Pilot Project
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 May 2019Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20250-11 years old7S Gamma GlobulinAffectAgeAllogenicAntibody-Secreting CellsAntigen PresentationAutoimmune DiseasesB blood cellsB cellB cell differentiationB cellsB lymphocyte differentiationB-CellsB-LymphocytesB-cellBacterial InfectionsBloodBlood CirculationBlood Reticuloendothelial SystemBlood SerumBlood leukocyteBlood monocyteBloodstreamBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCD14CD14 geneCD16CD16BCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell SignalingCellsChildChild YouthChildhoodChildren (0-21)ChronicClassificationCuesDataDendritic CellsDiagnosisDiseaseDisease ProgressionDisorderDown-RegulationEnvironmental FactorEnvironmental Risk FactorExposure toExpression SignatureFCGR3BFCGR3B geneFc Receptor III-1Fc gamma IIIb receptorFc-Gamma RIII-BetaFc-Gamma RIIIBFcRIIIBFungus DiseasesGWA studyGWASGene Expression ProfileGenerationsGeneticGenetic predisposing factorHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHumanIFNIgAIgGIgG Fc Receptor IIIBImmuneImmune Cell ActivationImmune systemImmunesImmunityImmunoglobulin AImmunoglobulin GImmunoglobulin-Secreting CellsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroIncidenceInducer CellsInducer T-LymphocytesInfectionInflammasomeInflammatoryInnate ImmunityInterferonsIntracellular Communication and SignalingLYT3LeukocytesLeukocytes Reticuloendothelial SystemLow Affinity IgG Fc Receptor IIIBLow Affinity Immunoglobulin Gamma Fc Region Receptor III-BLupus Erythematosus DisseminatusLupus GlomerulonephritisLupus NephritisLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMacrophageMarrow leukocyteMarrow monocyteMediatorMemory B CellMemory B-LymphocyteModern ManMycosesMyeloid CellsMφNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNuclear AntigensPBMCPathogenesisPathogenicityPathologicPathway interactionsPatientsPeripheral Blood Mononuclear CellPermeabilityPhenotypePilot ProjectsPlasmablastPlayPredisposition geneProliferatingRoleSLESentinelSerumShapesSignal TransductionSignal Transduction SystemsSignalingStimulusSurfaceSusceptibility GeneSystematicsSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTissuesVeiled CellsViral DiseasesVirus DiseasesWhite Blood CellsWhite Cellagesautoimmune conditionautoimmune disorderautoimmunity diseasebacteria infectionbacterial diseasebiological signal transductioncytokinedisseminated lupus erythematosusenvironmental riskfungal infectionfungus infectiongene expression patterngene expression signaturegenetic risk factorgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglobal gene expressionglobal transcription profileimmune activationimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinflammatory environmentinflammatory milieuinherited factorkidslymph glandlymph nodeslymphnodesmigrationmonocytenew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathogenpathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespediatricpilot studypredisposing generesponsesocial rolesusceptibility allelesusceptibility locussusceptibility variantsystemic autoimmune diseasesystemic autoimmune disordersystemic autoimmunitysystemic lupus erythematosistherapeutic biomarkertherapeutic markerthymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptometranscriptomicsviral infectionvirus infectionvirus-induced diseasewhite blood cellwhite blood corpusclewhole genome association analysiswhole genome association studyyoungster
Description preview
SUMMARY ACE Pilot Project; PI – Caielli, S.
Human monocytes (Mo) are bone marrow–derived leukocytes with important functions in
pathogen sensing and innate immunity during bacterial, viral, and fungal infections. Single-cell
transcriptomic data suggests that blood Mo are likely heterogeneous. During infections, circulating
Mo rapidly leave the…
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