grant
Picornavirus Genome Replication
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 20 Sept 2019Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AblationAchievementAchievement AttainmentAnabolismAppearanceBiochemicalBiological FunctionBiological ProcessCDP DiacylglycerolsCDP DiglyceridesCategoriesCell BodyCell FunctionCell LineCell NucleusCell PhysiologyCell ProcessCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessConsensusCytidine Diphosphate DiglyceridesCytidine DiphosphodiacylglycerolsCytoplasmDefectDevelopmentEctopic ExpressionEducational process of instructingEnterovirusEnzyme GeneEnzymesFBJ osteosarcoma oncogeneFOS geneFamilyFamily PicornaviridaeFatty AcidsG0S7Gene TranscriptionGenetic TranscriptionGenomeGlycerol PhosphoglyceridesGoalsHuman poliovirusHydantoinsImmunofluorescenceImmunofluorescence ImmunologicImpairmentInfectionInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsInstructionIsoformsLaboratoriesLife CycleLife Cycle StagesLigaseLigase GeneLipidsMammalian CellMembraneMonitorNon-Polyadenylated RNANucleusOrganellesPIP2Pathway interactionsPhosphatidesPhosphatidyl InositolPhosphatidylcholine BiosynthesisPhosphatidylglycerolsPhosphatidylinositol 4,5-BiphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol-4,5-BisphosphatePhosphatidylinositolsPhosphoinositidesPhospholipidsPicornaviridaePicornaviridae InfectionsPicornavirus InfectionsPicornavirusesPolio VirusPoliovirusProtein IsoformsProtein TraffickingProteinsProtooncogene FOSPtIns 4,5-P2PtdInsPtdInsP2Public HealthRNARNA ExpressionRNA Gene ProductsRNA VirusesResearchRibonucleic AcidStrains Cell LinesSubcellular ProcessSynthetasesTeachingTranscriptionTranslationsVaccinesVery Long Chain Fatty AcidVesicleViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirionVirusVirus AssemblyVirus DiseasesVirus ParticleVirus Replicationbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbiosynthesisc fosc-fos Genec-fos Proto-Oncogenescultured cell linedevelopmentalexperimentexperimental researchexperimental studyexperimentsfallsinhibitorinsightlife courselipidomemembrane biogenesismembrane structurenovelparalogparalogous geneparticlepathwayphosphatidyl glycerolpoliomyelitis virusposttranscriptionalprotein transportrecruittraffickingtranslationv-FOS FBJ Murine Osteosarcoma Viral Oncogene Homologviral assemblyviral infectionviral multiplicationviral replicationvirus infectionvirus multiplicationvirus proteinvirus-induced disease
Description preview
All positive-strand RNA viruses require host membranes for multiplication, even non-enveloped viruses like
poliovirus (PV). In some cases, viruses simply hijack host membranes and use them intact. However, in
other cases, viruses remodel the entire host lipidome to create virus-induced membranes with unique
phospholipid composition, which, in…
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