grant
Physiological determinants of suprathreshold deficits in sensorineural hearing loss
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 2 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY202521+ years oldAcousticsAdultAdult HumanAgeAnimal ModelAnimal Models and Related StudiesAnimalsAssayAttentionAudiogramAudiologyAudiometric TestAudiometryAuditoryBehaviorBehavioralBioassayBiological AssayBiological MarkersBrainBrain Nervous SystemBrain StemBrainstemCellular injuryClinicalCochleaCochlear OrganCodeCoding SystemCognitiveComplexCorti CellCuesDataDeafferentationDeafferentation procedureDevicesEEGEarplugElectroencephalogramElectroencephalographyEncephalonEnvironmentEquilibriumExclusionExhibitsFrequenciesHair CellsHearingHearing AidsHearing LossHearing TestsHumanHypoacusesHypoacusisImpairmentIndividualIndividual DifferencesInjuryInstitutionInternal EarLabyrinthLoudnessMeasuresMechanicsMemoryModelingModern ManNatureNoiseOutcomeParticipantPatient RecruitmentsPatientsPerceptionPerformancePeripheralPhysiologicPhysiologicalPsychoacousticsPsychophysicsReaction TimeRegistriesResearchResponse RTResponse TimeSensorineural DeafnessSensorineural Hearing LossSensorySensory Hearing LossSpeechSpeech PerceptionSpeech SoundTailTestingWorkadulthoodagesassistive hearing deviceassistive listening deviceauditory testsbalancebalance functionbasebasesbio-markersbiologic markerbiomarkercell damagecell injurycellular damagecohortdamage to cellsdysfunctional hearingear hair cellexperiencehearing amplificationhearing assessmenthearing assistancehearing assistive devicehearing challengedhearing defecthearing deficienthearing deficithearing devicehearing difficultyhearing dysfunctionhearing impairmenthearing in noisehearing loss therapyhearing loss treatmenthearing restorationhuman dataindexingindividual heterogeneityindividual variabilityindividual variationinjuriesinjury to cellsinner earinsightinterdisciplinary approachmechanicmechanicalmid lifemid-lifemiddle agemiddle agedmidlifemodel of animalmultidisciplinarymultidisciplinary approachneuralneural circuitneural circuitryneurocircuitrynoise perceptionparticipant recruitmentpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprogramspsychomotor reaction timepsychophysicalresponserestorationrestore hearingsensorineural hearing impairmentsoundsound frequencyspeech in background noisespeech in noisespeech in speech recognitionspeech recognition in noisestatisticssynaptic circuitsynaptic circuitrytreatment for hearing loss
Description preview
Project Summary/Abstract
Current assessments and treatments for hearing loss focus on restoring hearing sensitivity and speech
audibility through amplification. Yet, hearing-aid users struggle to understand audible speech, especially
in environments with background noise. Little is known about the precise physiological mechanisms that
contribute…
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