grant
Physiologic mechanisms of ion channel regulation
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Apr 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026AfricanArachidonic AcidsBindingBlood flowBreast CancerCalciumCardiacCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell Membrane LipidsCell SignalingCellsChloride ChannelsChloride Ion ChannelsChloridesDNA mutationDevelopmentDietDiseaseDisorderElectrolyte BalanceEmbryoEmbryonicEnvironmentEventFertilizationGenetic ChangeGenetic defectGenetic mutationGoalsHeart VascularHumanInnovative TherapyInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntracellular Communication and SignalingIon ChannelIonic ChannelsKO miceKnock-out MiceKnockout MiceKnowledgeLipidsMalignant Breast NeoplasmMalignant Pancreatic NeoplasmMalignant neoplasm of pancreasMediatingMembraneMembrane ChannelsMembrane LipidsModern ManMolecularMolecular InteractionMutationNerve CellsNerve UnitNeural CellNeurocyteNeuronsNull MouseOrganism-Level ProcessOrganismal ProcessPIP2Pancreas CancerPancreatic CancerPathologyPhosphatidesPhosphatidyl InositolPhosphatidylinositol 4,5-BiphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol-4,5-BisphosphatePhosphatidylinositolsPhosphoinositidesPhospholipidsPhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesPlatannaPolyunsaturated Fatty AcidsProcessPtIns 4,5-P2PtdInsPtdInsP2Public HealthRegulationResearchSensorySignal TransductionSignal Transduction SystemsSignalingTherapeuticXenopusXenopus laevisXenopus sp.biological signal transductioncirculatory systemclawed frogcraniofacialcraniofaciesdesigndesigningdevelopmentaldietseggexperimentexperimental researchexperimental studyexperimentsfertilizationsgenome mutationinnovateinnovationinnovativemalignant breast tumormembrane structureneuronalneuronal excitabilitypancreatic malignancyuterine contractility
Description preview
PROJECT SUMMARY
TMEM16A is a calcium-activated chloride channel that is required for numerous physiologic
processes, including regulation of neuronal and cardiac excitability, uterine contractility,
regulation of electrolyte balance, and sensory transduction. Their importance is supported by
the embryonic lethality of TMEM16A knockout mice, and by…
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