grant
Physical Chemistry of Nucleic Acids
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 1 Jul 1983Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AdoptedAffectAssayBinding ProteinsBioassayBiological AssayCHD1CHD1 geneCell BodyCellsChaperoneChromatinChromodomain Helicase DNA-Binding Protein 1Cryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyDNADNA-Dependent RNA Polymerase IIDeoxyribonucleic AcidDrosophilaDrosophila genusElectron CryomicroscopyElongation FactorEmbryoEmbryonicEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEukaryotic CellFKHRFOXO1FOXO1AFOXO1A geneFluorescenceForkhead Box O1AForkhead in RhabdomyosarcomaGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGenomeGenomic DNAHistone H1HistonesIn VitroIndividualIonic StrengthsLengthLigand Binding ProteinLigand Binding Protein GeneMeasurementMechanicsMethodsModalityModificationMolecularMolecular ChaperonesMonitorNucleic AcidsNucleosomesPhysical ChemistryPlayPolymerasePositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein BindingProtein ModificationProteinsRNA ExpressionRNA Polymerase BRNA Polymerase IIRegulationRepressionResolutionRoleSolventsSpectroscopySpectrum AnalysesSpectrum AnalysisStructureTranscriptionTranscription ElongationVariantVariationbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesbound proteinconfocal imagingcryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopyelectron cryo-tomographyepigeneticallyexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblefruit flygDNAin vivoin vivo fluorescence imagingin-vivo fluorescence imaginglaser tweezerlive cell imagelive cell imaginglive cellular imagelive cellular imagingmechanicmechanicalmechanical propertiesoptic tweezeroptical trapsoptical tweezersparticleprotein crosslinkreconstructionresolutionssingle moleculesocial roletomography
Description preview
Project Summary
In eukaryotic cells, the packaging of genomic DNA into nucleosomes represents the basic barrier to
transcription by RNA polymerase II (Pol II). The dynamic modulation of the magnitude of this barrier and the
degree of chromatin compaction constitute fundamental mechanisms of regulation of gene expression. Having
previously…
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