grant
Physical Activity, Energy Balance, and Cancer
Organization DIVISION OF CANCER EPIDEMIOLOGY AND GENETICSLocation UNITED STATES
NIHUS FederalResearch GrantFY2025(TNF)-αB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Binding ProteinsBiologicalBiological MarkersBody Weight decreasedBreast CancerCachectinCaloric IntakeCancer and NutritionCancersCausalityColorectal CancerEnergy IntakeEstrogensEtiologyGoalsGrowth AgentsGrowth FactorGrowth SubstancesHPGFHepatocyte-Stimulating FactorHybridoma Growth FactorIFN-beta 2IFNB2IGF-1IGF-Binding Protein 3IGF-IIGF-I-SmCIGFBP-3IL-6IL6 ProteinIncidenceInflammatoryInsulin-Like Growth Factor 1Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Somatomedin Peptide IInterleukin-6Ligand Binding ProteinLigand Binding Protein GeneMGI-2Macrophage-Derived TNFMalignant Breast NeoplasmMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMonocyte-Derived TNFMyeloid Differentiation-Inducing ProteinObesityOutputPancreas CancerPancreatic CancerPhenotypePhysical activityPlasmacytoma Growth FactorProtein BindingProteins Growth FactorsSHBGSHBG geneSedentary behaviorSedentary life-styleSex Hormone-Binding Globulin GeneSomatomedin CTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestosteroneTherapeutic EstrogenTherapeutic Steroid HormoneTherapeutic TestosteroneTrans-TestosteroneTumor Necrosis FactorTumor Necrosis Factor-alphaWeight GainWeight IncreaseWeight LossWeight Reductionadipositybio-markersbiologicbiologic markerbiomarkerbody weight gainbody weight increasebody weight lossbound proteincaloric dietary contentcancer preventioncancer riskcausationcorpulencecytokinedisease causationenergy balanceimprovedinterferon beta 2malignancymalignant breast tumormetabolism measurementmetabolomicsmetabonomicsmultidisciplinaryneoplasm/cancernovelpancreatic malignancysedentary lifestylesteroid hormonewt gainwt-loss
Description preview
The goals will be achieved by a) evaluating obesity, energy balance, and physcial activity in relation to cancer incidence and survival; b) Improving assessment of energy intake, output, and body phenotype; c) Evaluating biomarkers to determine mechanisms including inflammatory cytokines (CRP, IL-6, TNF-alpha), growth factors and their major…
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