grant
Photoresponsive materials to study matricellular signaling dynamics during crypt formation and fission
Organization UNIVERSITY OF COLORADOLocation Boulder, UNITED STATESPosted 1 Aug 2019Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20262-photon3-D Imaging3D imagingAdhesivesAllelesAllelomorphsAutoregulationBiomechanicsBody TissuesCancersCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell FunctionCell PhysiologyCell ProcessCell ShapeCell SignalingCell secretionCell to Cell Communication and SignalingCell-Cell SignalingCell-Extracellular MatrixCellsCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessCellular SecretionCellularityComplexCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderDaughterDevelopmentDigestionDiseaseDisorderECMEngineeringEpithelial CellsEpitheliumEventExtracellular MatrixGI Stem cellGeometryGranulomatous EnteritisHG38HealthHomeostasisHydrogelsIn VitroInfectionInflammatory Bowel DiseasesInflammatory Bowel DisorderInjuryIntegrin BindingIntestinalIntestinal DiseasesIntestinal DisorderIntestinesIntracellular Communication and SignalingLGR5LGR5 geneLabelLettersLightLocationMaintenanceMalignant NeoplasmsMalignant TumorMechanical Signal TransductionMechanosensory TransductionMediatingMembraneMiceMice MammalsMicroscopyModelingModulusMurineMusMyosin Heavy ChainsNatural regenerationNuclearNutrientOrganoidsPaneth CellsParentsPatternPeptidesPhotoradiationPhysiological HomeostasisPositionPositioning AttributeProcessPropertyProtein SecretionRegenerationReporterReproducibilityResearchRoleShapesSignal TransductionSignal Transduction SystemsSignalingSmall IntestinesStructureSubcellular ProcessTamoxifenTestingThree-Dimensional ImagingTimeTissuesUlcerated ColitisUlcerative ColitisValidationVillusbasebasesbiological signal transductionbiomechanicalbowelcell typecrypt celldensitydevelopmentaleleocolitisexperimentexperimental researchexperimental studyexperimentsextracellulargastrointestinal stem cellgut progenitorgut stem cellhigh definitionhigh-resolutionin vitro Modelin vivoin vivo Modelinflammatory disease of the intestineinflammatory disorder of the intestineinjuriesinjury and repairinnovateinnovationinnovativeintegrin boundintercellular communicationintestinal autoinflammationintestinal cryptintestinal progenitorintestinal stem cellsintestine diseaseintestine disorderknock-downknockdownmalignancymechanosensingmechanotransductionmembrane structuremouse modelmurine modelmyosin heavy chainneoplasm/cancernon-natural amino acidsnon-proteinogenic amino acidsnonproteinogenic amino acidsnutrient absorptionparentprogenitor cell nicheprogenitor nicheregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregional enteritisrepairrepairedresponsesmall bowelsocial rolespatial and temporalspatial temporalspatiotemporalstem and progenitor cell nichestem cell nichetissue regenerationtissue regrowthtissue renewaltissue specific regenerationtwo-photonunnatural amino acidsvalidations
Description preview
ABSTRACT
The small intestine is lined with a single layer of epithelial cells that is organized into crypt-villus units. These epithelial
cells perform multiple functions, such as aiding in digestion, nutrient absorbance, and serving as a barrier, but these
processes also damage the epithelial layer. As a result, intestinal stem cell (ISCs)…
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