grant
Phospholipid and Sphingolipid Signaling in Drosophila
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Anti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsApoptosisApoptosis PathwayBiological FunctionBiological ProcessBrainBrain Nervous SystemCancer DrugCancer TreatmentCancersCausalityCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCellular ExpansionCellular GrowthCeramidesCessation of lifeChemotherapy ProtocolChemotherapy RegimenChemotherapy-Oncologic ProcedureClinicalCombination Chemotherapy RegimenDAG lipaseDeathDevelopmentDiacylglycerol LipaseDietary FatsDiglyceride LipaseDiseaseDisorderDrosophilaDrosophila genusEncephalonEnvironmentEnzyme GeneEnzymesEtiologyFailureFat BodyGenerationsGenesGeneticHeparin-Clearing FactorHumanHumulin RHyperglycemiaHyperlipemiaHyperlipidemiaInhibition of ApoptosisInsulinIntermediary MetabolismIntracellular Communication and SignalingInvestigationInvestigatorsLinkLipaseLipemia-Clearing FactorLipidsLipoprotein (a)Lipoprotein Lp(a)Lp(a)Malignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMetabolic PathwayMetabolic ProcessesMetabolismMidgutModern ManMolecularMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantNeoplastic Disease Chemotherapeutic AgentsNovolin RPeptidesPhosphatidesPhospholipidsPhysiologicPhysiologicalPhysiologyPost-Heparin LipasePostheparin LipasePostheparin Lipoprotein LipaseProcessProgrammed Cell DeathProliferatingProteinsPublishingQuimioterapiaRegular InsulinRegulationResearchResearch PersonnelResearchersResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugSignal TransductionSignal Transduction SystemsSignalingSphingolipidsStructureTranslatingTriacylglycero-protein acylhydrolaseTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriolean HydrolaseTumor-Specific Treatment Agentsanti-cancer druganti-cancer therapybasebasesbiological signal transductioncancer cellcancer chemotherapycancer therapycancer-directed therapycausationcell growthceramide 1-phosphateceramide kinasechemotherapyclearing factor lipasedevelop drug resistancedevelopmentaldiabeticdietary lipiddisease causationdrug resistance developmentexperimentexperimental researchexperimental studyexperimentsfruit flygut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghyperglycemicin vivoinsulin secretioninsulin-like peptidelipoprotein lipasemalignancymulti-drug resistantmultidrug resistantmutantnecrocytosisneoplasm/cancerparticleproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialresponsesuccesstherapeutically effectivetriacylglycerol protein acylhydrolasetributyrase
Description preview
Ceramide kinases are involved in the generation of ceramide 1-phosphate from ceramide and thus regulate Ceramide mediated biological functions. In our previous studies we had identified genetic interactors of ceramide kinase. One of the enzymes unregulated in a ceramide kinase mutant was a lipase secreted in the gut. In a study published recently…
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