grant
Phosphoinositide Signaling in Cytosol and Nucleus
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Jan 2020Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20261-Phosphatidylinositol 3-KinaseAgonistAntioncogene Protein p53BiologyCancersCell Communication and SignalingCell FunctionCell NucleusCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell membraneCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessCellular Tumor Antigen P53ChemicalsCofactor Protein SComplexCytoplasmic MembraneCytosolDNA DamageDNA Damage RepairDNA InjuryDNA RepairDNA Repair GeneDNA mutationDNA repair proteinDegenerative Neurologic DisordersDiseaseDisorderEGFEGF geneEndosomesEventGenerationsGenetic ChangeGenetic defectGenetic mutationInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntracellular Communication and SignalingIntracellular Second MessengerKinasesLinkMAP4Malignant NeoplasmsMalignant TumorMediatingMembraneMicro-tubuleMicrotubulesMolecularMutationNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNuclearNuclear ProteinsNucleusOncogenicOncoprotein p53P53PDK1PDPK1PDPK1 genePI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePIP2PRO0461Pathway interactionsPhosphatesPhosphatidyl InositolPhosphatidyl Inositol PhosphatesPhosphatidylinositol 3-KinasePhosphatidylinositol 4,5-BiphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol PhosphatesPhosphatidylinositol-3-OH KinasePhosphatidylinositol-4,5-BisphosphatePhosphatidylinositolsPhosphoinositide 3-HydroxykinasePhosphoinositidesPhosphoprotein P53Phosphoprotein pp53PhosphorylationPhosphotransferase GenePhosphotransferasesPlasma MembranePlayPolyphosphoinositidesProtein PhosphorylationProtein SProtein TP53ProteinsPtIns 4,5-P2PtdInsPtdIns 3-KinasePtdInsP2ReceptosomesRegulationResearch Project SummariesRoleSecond Messenger SystemsSecond MessengersSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStressSubcellular ProcessTP53TP53 geneTRP53TherapeuticTransphosphorylasesTumor Protein p53Tumor Protein p53 GeneTumor Suppressor ProteinsType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseUnscheduled DNA SynthesisVitamin K-Dependent Protein SWorkbiological adaptation to stressbiological signal transductioncell growthdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesgenome mutationinorganic phosphatemalignancymembrane structuremicrotubule associated protein 4mutantneoplasm/cancerneurodegenerative illnessp53 Antigenp53 Genesp53 Tumor Suppressorpathwayplasmalemmaprotein p53reaction; crisisresponsescaffoldscaffoldingsignal transduction second messengerssocial rolespatial and temporalspatial temporalspatiotemporalstress responsestress; reactiontumor suppressor
Description preview
Project Summary
The research proposed seeks to reveal mechanisms for spatial phosphoinositide (PI) signaling in the cytosol
and nucleus. These pathways have broad implications for cancer, neurodegenerative disorders, and other
diseases. PI signaling generates seven distinct polyphosphoinositide (PIPn) messengers. EGF and other
agonists activate…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click