grant
Phosphoinositide-calcium Signaling In Cell Regulation
Organization EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTLocation UNITED STATES
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 4-Kinase4-ethoxymethylene-2-phenyl-2-oxazoline-5-oneATP-protein phosphotransferaseAffectAlbers-Schoenberg DiseaseAlbers-Schonberg diseaseAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseApoptosisApoptosis PathwayAutoregulationBindingBinding ProteinsBiochemical PathwayBiochemical ProcessBiological FunctionBiological ProcessBioluminescenceBiosensorBlindnessBone ResorptionCalcium Ion SignalingCalcium SignalingCanadaCancersCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell LocomotionCell Membrane LipidsCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCell Surface ReceptorsCell membraneCellsCellular FunctionCellular MembraneCellular Metabolic ProcessCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessChiro-InositolChloridesCollaborationsCommunitiesComplexCytoplasmic MembraneDNA mutationDegenerative Neurologic DisordersDevelopmentDiabetes MellitusDictyostelium discoideumDiseaseDisorderEC 2.7.1.67ElementsEndocrine Gland SecretionEnergy TransferEngineeringEnsureEnvironmentEnzyme GeneEnzymesEsteroproteasesEukaryotic CellEvaluation ReportsFamilyFamily PicornaviridaeFocus GroupsG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGehrig's DiseaseGenerationsGenetic ChangeGenetic defectGenetic mutationGrowth AgentsGrowth FactorGrowth SubstancesGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsH+ elementHomeostasisHormonesHost FactorHost Factor ProteinHumanHydrogen IonsImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImpairmentIndividualInfectionInositide PhospholipidsInositolInositol PhosphoglyceridesInositol PhospholipidsIntegration Host FactorsInterceptIntracellular Communication and SignalingIon ChannelIonic ChannelsKinase Family GeneKinasesLife CycleLife Cycle StagesLigand Binding ProteinLigand Binding Protein GeneLinkLipidsLou Gehrig DiseaseLysosomesMacrophageMalignant NeoplasmsMalignant TumorMammaliaMammalian CellMammalsMarble Bone DiseaseMeasurementMediatingMembraneMembrane ChannelsMembrane LipidsMembrane Transport ProteinsMembrane TransportersMesoinositolMetabolic NetworksMinorModern ManMolecularMolecular InteractionMolecular TargetMonitorMutationMutation AnalysisMφNPIKNamesNerve DegenerationNerve Transmitter SubstancesNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeurotransmittersOrganellesOsteoclastic Bone LossOsteoclastsOsteopetrosisOsteosclerosis FragilisPI 4-KinasePI4K92PI4KBetaPathway interactionsPatientsPeptidasesPeptide HydrolasesPhagocytesPhagocytic CellPhagosomesPhosphatesPhosphatidesPhosphatidyl InositolPhosphatidyl Inositol PhosphatesPhosphatidylinositiol KinasePhosphatidylinositol 4-KinasePhosphatidylinositol 4-Kinase BetaPhosphatidylinositol 4-Kinase, Catalytic, BetaPhosphatidylinositol 4-Kinase, Type III, BetaPhosphatidylinositol Kinase Type IIPhosphatidylinositol PhosphatesPhosphatidylinositolsPhosphoinositide KinasePhosphoinositide-4-Kinase Catalytic Beta PolypeptidePhosphoinositidesPhospholipidsPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPicornaviridaePicornavirusesPlasma MembranePlayPolyphosphoinositidesPopulationProcessProductionProgrammed Cell DeathProliferatingProtease GeneProteasesProtein BindingProtein KinaseProteinasesProteinsProteins Growth FactorsProteolytic EnzymesProtonsPtdINS4PPtdInsPtdIns 4-KinasePtdIns(3,5)P2RegulationReportingResearchResolutionRestRoleSignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSiteSpecificitySubcellular ProcessSurfaceSystemTherapeutic HormoneTransmissionTransphosphorylasesVirusWortmannin-Sensitive Phosphatidylinositol 4-Kinaseamebocyteanti-microbial agentanti-microbial drugantiporterbiological sensorbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbound proteincausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell metabolismcell motilitycellular differentiationcellular metabaolismcellular targetingcombatdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelop therapydevelopmentaldiabetesdisease causing variantdisease-causing alleledisease-causing mutationfightinggastrointestinalgenome mutationglycogen synthase a kinasehuman diseasehydroxyalkyl protein kinaseinformation processinginhibitorinorganic phosphateintervention developmentlife courselive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignancymarble bonemembrane structuremouse modelmurine modelmutantnamenamednamingneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathogenpathogenic allelepathogenic variantpathwayphOxphOx-onephosphatidylinositol 3,5-biphosphatephosphatidylinositol 3,5-bisphosphatephosphatidylinositol 3,5-diphosphatephosphatidylinositol 4-monophosphatephosphatidylinositol 4-phosphatephosphorylase b kinase kinaseplasmalemmaprotein complexreal time monitoringrealtime monitoringrecruitresolutionsresponsesocial rolesorting nexinstherapy developmenttooltraffickingtransmission processtreatment developmentvision lossvisual loss
Description preview
Every biochemical process that happens in a eukaryotic cell relies upon a molecular information flow that leads from cell surface receptors that inform the cell about its environment all the way to the molecular effectors that determine the appropriate cellular response. A proper information transmission requires a high degree of organization…
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