grant
Phospho- and natural-variant regulation of heterotrimeric G protein signaling
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 6 May 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026Amino Acid SequenceArabidopsisArabidopsis thalianaBenignBiochemistryBiological ChemistryCell BodyCell Communication and SignalingCell SignalingCellsCommunicable DiseasesComplementComplement ProteinsCouplingCritical PathsCritical PathwaysDNA mutationDiseaseDisease OutcomeDisorderElectrophysiologyElectrophysiology (science)EpistasisEpistatic DeviationG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG(s), alpha SubunitG(s), α SubunitG(s)alphaG(s)αG-Protein-Coupled ReceptorsG-ProteinsGPCRGTPGTP PhosphohydrolasesGTP-Binding Protein alpha Subunits, GsGTP-Binding Protein α Subunits, GsGTP-Binding ProteinsGTP-Regulatory ProteinsGTPasesGenetic ChangeGenetic DiseasesGenetic EpistasisGenetic defectGenetic mutationGenomeGenotypeGoalsGs alpha Family G-ProteinGsαGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGuanosine TriphosphateGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesGαsHealthHeterotrimeric G-ProteinsHeterotrimeric GTP-Binding ProteinsHeterozygoteHumanImageImpairmentInbreedingIndividualInfectious DiseasesInfectious DisorderInteraction DeviationInterventionIntracellular Communication and SignalingLaboratoriesLigand BindingMedicalMembraneMethodsMissense MutationModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryMouse-ear CressMutationNatureNeurophysiology / ElectrophysiologyOrganismPathway interactionsPenetrancePhenotypePhosphorylationPlant ModelPlantsPrimary Protein StructureProtein BiochemistryProtein ConformationProtein PhosphorylationProtein SubunitsProtein/Amino Acid BiochemistryProteinsRegulationRegulatory Ns ProteinRegulatory ProteinResearchScienceSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSingle Base PolymorphismSingle Nucleotide PolymorphismSiteStimulatory Gs G-ProteinSystemTherapeuticVariantVariationWhole Organismalpha Subunit Stimulatory GTP-Binding Proteinalpha-Gsbiological signal transductioncomplementationconformationconformationalconformational stateconformationallyconformationsdimerelectrophysiologicalepistatic interactionepistatic relationshipgene manipulationgene x gene interactiongenetic conditiongenetic disordergenetic epistasesgenetic manipulationgenetic regulatory proteingenetically manipulategenetically perturbgenome mutationguanosinetriphosphataseheterozygosityimagingliving systemmembrane structuremissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmolecular phenotypepathwayphenomeprotein functionprotein sequenceregulatory gene productrepairrepairedsingle nucleotide variantα-Gs
Description preview
Project Summary/Abstract
Numerous cellular signaling pathways of critical importance to organism health rely on heterotrimeric G
protein signaling. Heterotrimeric G proteins are composed of Gα, Gβ, and Gγ subunits. Classically, ligand binding
to transmembrane G-protein-coupled-receptors (GPCRs) elicits conformational changes that lead to exchange…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click