grant
Phenotyping and Predicting Ultrafiltration Intolerance to Guide Transitions from Continuous to Intermittent Kidney Replacement Therapy
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AbscissionAcuteAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAddressBlood PlasmaBlood PressureBlood VesselsChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCirculatory CollapseClassificationClinicalCritical CareCritical IllnessCritically IllDataData AnalysesData AnalysisData BasesData SetDatabasesDialysisDialysis procedureDysfunctionElectronic Health RecordElectronicsEquationEventExcisionExposure toExtirpationFluid BalanceFluid HomeostasisFluid overloadFunctional disorderGoalsHealth systemHemodialysesHemodialysisHospital AdmissionHospitalizationHospitalsHourHypotensionIndividualIntensive Care UnitsInterventionKidney FailureKidney InsufficiencyKidney Replacement TherapyKnowledgeLiquid substanceLow Blood PressureMachine LearningMaintenanceMeasuresMethodsModalityModelingMonitorObservational StudyOpticsOrganPatient riskPatientsPatternPerformancePhenotypePhysiopathologyPlasmaPlasma SerumPredictive ValuePreparednessProspective StudiesProviderReadinessRecoveryRecurrenceRecurrentRemovalRenal FailureRenal InsufficiencyRenal Replacement TherapyRenal functionResearchResidualResidual stateResolutionReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleShockSpecific qualifier valueSpecifiedStressSurgical RemovalSymptomsSystematicsTechnologyTestingTimeTranslatingUltrafiltrationValidationVascular Hypotensive DisorderWorkacute kidney injuryanalyzing longitudinalchronic kidney diseasecirculatory shockclinical relevanceclinical riskclinical validationclinically relevantcohortcomputer based predictiondata basedata interpretationdialysis therapyelectronicelectronic deviceelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic health systemelectronic medical health recordfluidhemodynamicshypervolemiahypoperfusionimprovedinnovateinnovationinnovativeinsightkidney functionlife-sustaining therapyliquidlongitudinal analysismachine based learningmachine learned algorithmmachine learning algorithmmachine learning based algorithmmodel developmentmodel developmentsmultidisciplinarynovelobservational research studyobservational surveyopticalpathophysiologypredictive modelingpredictive toolsprospectiveprospective research studyprospective surveyreconstitutereconstitutionresectionresolutionsresponserisk prediction algorithmrisk prediction modelrisk prediction systemrisk prediction toolshockssocial roletoolvalidationsvascular
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Project Summary
Dialysis is an important life-sustaining therapy for kidney failure in the critical care setting, and a crucial
method for volume management for patients with either severe acute kidney failure or chronic kidney failure.
While most patients will initiate continuous kidney replacement therapy (CKRT) in the intensive care unit, many…
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