grant
Phenotypic consequences of lipoprotein(a)
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 15 Jan 2025Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2026ASCVDAbdominal Aortic AneurysmAddressAdult-Onset Diabetes MellitusAdverse effectsAffectAfricanAfrican AmericanAfro AmericanAfroamericanAnemiaAnthropologyAssayAtherogenicityAtherosclerosisAtherosclerotic Cardiovascular DiseaseBioassayBiological AssayBleedingBlood VesselsCardiac infarctionCausalityCerebral Brain HemorrhageCerebral HemorrhageCerebral Parenchymal HemorrhageCerebral hemisphere hemorrhageCerebrum HemorrhageClinicalCopy Number PolymorphismDataDecision MakingDiseaseDisorderEast AsianEpidemiologyEtiologyEuropeanEvaluationFoundationsFutureGWA studyGWASGene variantGeneticGenotypeHealthHeart failureHematologyHemorrhageHeritabilityHispanicIndigenousIndividualInflammatoryInfluentialsIntracerebral HemorrhageInvestigationKetosis-Resistant Diabetes MellitusKringle DomainsKringlesLatinoLipoprotein (a)Lipoprotein Lp(a)LipoproteinsLong-term cohortLongitudinal cohortLp(a)MapsMaturity-Onset Diabetes MellitusMeasurementMeasuresMedicineMendelian randomizationMetabolicMethodsModelingMyocardial InfarctMyocardial InfarctionNIDDMNational Institutes of HealthNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusParticipantPersonsPhenotypePolynesianPopulationPopulation GeneticsPublic HealthPulmonary Body SystemPulmonary Organ SystemResearchRespiratory SystemRespiratory TractsRespiratory tract structureRisk FactorsRoleSlow-Onset Diabetes MellitusSouth AmericanSouth AsianStable Diabetes MellitusStatistical MethodsT2 DMT2DT2DMTherapeuticTherapeutic EffectTherapy Clinical TrialsType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited States National Institutes of Healthadult onset diabetesallelic variantatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebiobankbiorepositoryblood losscardiac failurecardiac infarctcardiovascular disease riskcardiovascular disorder riskcausationcohortcopy number variantcopy number variationcoronary attackcoronary infarctcoronary infarctiondisease causationepidemiologicepidemiologicalevidence basegenetic architecturegenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variantheart attackheart infarctheart infarctioninsightinterestketosis resistant diabetesmaturity onset diabetesnovelphenotypic datapolygenetic risk scorespolygenic risk scorerisk minimizationsocial rolestatistic methodsthrombotictype 2 DMtype II DMtype two diabetesvascularvenous thromboembolismwhole genome association analysiswhole genome association study
Description preview
ABSTRACT
Lipoprotein(a) [Lp(a)], a highly atherogenic, prothrombotic, and proinflammatory lipoprotein, is a causal, independent, and highly heritable (h2=70-90%) atherosclerotic cardiovascular disease (ASCVD) risk factor that is elevated in 1.5 billion people globally. Despite significant stakes and emerging therapies that can reduce Lp(a) by…
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