grant

Phenotype-Tailored Lifestyle intervention for Obesity: A Randomized Trial

Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 15 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202521+ years oldAccelerationAddressAdherenceAdultAdult HumanAnti-Obesity AgentsAnti-Obesity DrugsAnxietyAutoregulationBMIBMI percentileBMI z-scoreBariatricsBehaviorBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBlindedBody Weight ChangesBody Weight decreasedBody mass indexCaloriesChronicClassificationClinical Cooperative GroupsClinical ResearchClinical StudyClinical Trial GroupsClinical TrialsClinical Trials Cooperative GroupConditioning TherapyConsumptionCounselingDataDevicesDietDiseaseDisorderDysfunctionEatingEmotionsEndocrine Gland SecretionEndoscopyEnergy ExpenditureEnergy MetabolismFood IntakeFunctional disorderGastric EmptyingGene variantGoalsHomeostasisHormonesHourHungerInterval trainingLeannessLife StyleLifestyleLifestyle TherapyLong-Term EffectsMachine LearningMaintenanceMethodsNamesObesityObesity EpidemicOutcomeParticipantPathogenesisPatientsPersonalized medical approachPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPrevalenceProceduresProspective cohortProteinsPublishingQuetelet indexRadiation exposureRadioactive IsotopesRadioisotopesRadionuclidesRandomization trialRandomizedRecommendationRelapseReportingResearchRestRewardsSatiationSupplementationSystematicsTestingTherapeutic HormoneThinnessTimeValidationWeight ChangeWeight LossWeight Reductionadiposityadult adiposityadult obesityadulthoodadults with obesityallelic variantanti-obesity compoundsanti-obesity medicationsanti-obesity therapeuticsattenuationbehavior interventionbehavior phenotypebehavioral interventionbehavioral phenotypingbiomarker performancebiomarker utilitybody weight lossclinical applicabilityclinical applicationclinical practicecohortcompare interventioncomparison interventioncorpulencecustomized therapycustomized treatmentdesigndesigningdetermine efficacydietsefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationemotional eateremotional eatingendoscopic imagingenergy balanceevaluate efficacyevidence baseexamine efficacygastrointestinalgenetic variantgenomic variantgroup interventionimprovedindividualized approachindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentindustrial partnershipindustry partnerindustry partnershipintervention designintervention programlife style interventionlifestyle interventionmachine based learningnamenamednamingnew markernovel biomarkernovel markerobese patientsobesity interventionobesity therapyobesity treatmentpathophysiologypatient specific therapiespatient specific treatmentpatients with obesitypersonalized approachphenotypic biomarkerphenotypic markerprecision approachpredict responsivenesspredicting responsepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreservationrandomisationrandomizationrandomized trialrandomized, clinical trialsrandomly assignedresponsesatietystomach emptyingtailored approachtailored medical treatmenttailored therapytailored treatmenttherapy designtraittreatment designunique treatmentvalidationsweight loss interventionweight loss programweight loss programmingweight loss therapyweight loss treatmentwt-loss
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PROJECT SUMMARY
Obesity is a chronic, relapsing, and multifactorial disease, with a prevalence of 42%. Obesity treatment is

challenging in clinical practice because of the physiologic and behavioral adaptations that occur during the

weight-reduced state to preserve energy. Our overall goal is to develop an evidence-based, phenotype-guided

approach…

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Phenotype-Tailored Lifestyle intervention for Obesity: A Randomized Trial — MAYO CLINIC ROCHESTER | UNITED STATES | Jul | Dev Procure