grant
Phenotype-based Screens to Identify Genetic Factors Associated with Gametocyte Development in Plasmodium falciparum
Organization UNIVERSITY OF SOUTH FLORIDALocation TAMPA, UNITED STATESPosted 12 Nov 2024Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY20250-11 years oldAfrica South of the SaharaAnophelesAnopheles GenusAnophelinesBiologyBloodBlood CellsBlood Reticuloendothelial SystemCell BodyCellsCellular MatrixChildChild YouthChildren (0-21)Chromosome MappingClinicalCollectionComplexCoupledCryofixationCryopreservationCulicidaeCytoskeletal SystemCytoskeletonDataDefectDevelopmentDifferential Gene ExpressionEventExpression SignatureFatty AcidsFemaleGene ExpressionGene Expression ProfileGene LocalizationGene MappingGene Mapping GeneticsGene ModifiedGeneralized GrowthGenesGeneticGenetic ScreeningGenetics-MutagenesisGenomeGenomic approachGenomicsGenotypeGrowthHarvestHeat ShockHeat-Shock ReactionHeat-Shock ResponseHumanInfectionIngestionLibrariesLinkLinkage MappingMagnetismMalariaMetabolic PathwayModern ManMorbidityMorbidity - disease rateMosquitoesMutagenesisMutagenesis Molecular BiologyP falciparumP. falciparumP.falciparumPaludismPatternPeripheral Blood CellPersonsPhasePhenotypePlasmodiumPlasmodium InfectionsPlasmodium falciparumPopulationPregnant WomenProcessPropertyProteinsProtocolProtocols documentationRNA SplicingRNA metabolismRegulationResolutionSalivary GlandsSiteSplicingSporozoitesSub-Saharan AfricaSubsaharan AfricaTimeTissue GrowthTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTotal Human and Non-Human Gene MappingValidationasexualbio-informatics toolbioinformatics toolblood mealcold preservationcold storagedevelopmentalexpectant motherexpectant womenexpecting motherexpecting womenexperiencefunctional genomicsgene expression patterngene expression signaturegene functiongene interactiongene modificationgene networkgenetic mappinggenetically modifiedgenome scalegenome-widegenomewidegenomic effortgenomic strategygraph theoryimprovedindividuals who are pregnantingestintracellular skeletonkidsmachine learning based methodmachine learning methodmachine learning methodologiesmagneticmalemortalitymutantontogenypeople who are pregnantpregnant femalespregnant motherspregnant peoplepregnant populationsresolutionsscRNA sequencingscRNA-seqscreeningscreeningssex determinationsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingthose who are pregnanttooltraffickingtranscriptional profiletranscriptional signaturevalidationswomen who are pregnantyoungster♀♂
Description preview
Project Summary/Abstract
Plasmodium falciparum is the major global cause of malaria morbidity and mortality and is especially
devastating in pregnant women and children in sub–Saharan Africa. Anopheline mosquitoes are essential for
the spread of new infections, requiring ingestion of mature sexual stages from an infected person and then a
second…
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