grant
Pharmacomicrobiomics: The Frontier of Interindividual Variability in Drug Response
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 15 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20254-methylumbelliferone7-hydroxy-4-methyl-coumarin7-hydroxy-4-methylcoumarinAccidentsAdverse ExperienceAdverse drug effectAdverse eventAliquotAutologousAutomobile DrivingBacteriaBeta-glucuronidaseBiliaryBody TissuesCirculationClinicalConstipationCulturing, in vitro Vertebrate, PrimaryDataDevelopmentDiarrheaDrug Side EffectsDrug toxicityDrug usageDrugsEmesisEndotheliumEnzyme GeneEnzymesEpithelial CellsExcretory functionFecesFutureGI microbiomeGI microbiotaGastrointestinal microbiotaGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGlucuronidaseGlucuronidase InhibitorGlucuronidesGoalsHomeHost FactorHost Factor ProteinHumanImmuneImmunesIn VitroIncubatedIndividualInjuryIntegration Host FactorsInterdisciplinary ResearchInterdisciplinary StudyIntermediary MetabolismIntestinalIntestinal AbsorptionIntestinesInvestigatorsLeadMediatingMedicationMentorsMetabolic ProcessesMetabolismMethodsMicrobeMissionModelingModern ManMolecularMultidisciplinary CollaborationMultidisciplinary ResearchNauseaOralOrganPBPKPb elementPersonsPharmaceutical PreparationsPhasePhenotypePhysiologyPopulationPositionPositioning AttributePostdocPostdoctoral FellowPre-Clinical ModelPreclinical ModelsPredispositionPrimary Cell CulturesProteomicsPublic HealthQOLQuality of lifeReactionReaderRecommendationReporterReportingResearchResearch AssociateResearch PersonnelResearchersSamplingScientistSiteStromal CellsSulfatasesSusceptibilitySystemTestingTextTherapeuticTissuesToxic effectToxicitiesTractionTrainingTranscript Expression AnalysesTranscript Expression AnalysisValidationVomitingWorkabsorptionalter microbiomeanalytical methodanalyze gene expressionazoreductasebacteria metabolismbacterial metabolismbeta-D-Glucuronidase Inhibitorsbeta-D-Glucuronoside glucuronosohydrolasebeta-Glucuronidase Inhibitorsbowelcareercell typedashboarddepositorydevelopmentaldigestive tract microbiomedrivingdrug dispositiondrug metabolismdrug usedrug-related adverse effectsdrug/agententeric microbial communityenteric microbiomeenteric microbiotaexcretionexperiencefecal samplefrontiergastrointestinal absorptiongastrointestinal microbial floragastrointestinal microbiomegene expression analysisgene expression assaygene manipulationgenetic manipulationgenetically manipulategenetically perturbgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomeheavy metal Pbheavy metal leadhomesimprovedinjuriesinter-individual variabilityinter-individual variationintestinal biomeintestinal epitheliumintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraisolated individualsisolated peoplelonely individualslonely peoplemicrobial consortiamicrobial floramicrobiome adaptationmicrobiome alterationmicrobiome perturbationmicrobiotamicrofloramonolayermultispecies consortianext generationnovelpharmacokinetic modelpharmacovigilancephenotypic biomarkerphenotypic markerphysiologically based pharmacokineticspost-docpost-doctoralpost-doctoral traineepre-clinical developmentprecision medicineprecision-based medicinepreclinical developmentpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreferencepreventpreventingprogramsprotein expressionrepositoryresearch associatesresponsescRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstoolstool samplestool specimentooltranscriptional profilingvalidationsβ-D-Glucuronoside glucuronosohydrolaseβ-glucuronidase
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Many medications are modified by intestinal bacteria, positioning them as an emerging and signif- icant driver of overall drug response (efficacy and toxicity) beyond host factors. Considering the importance of…
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