grant
Pharmacology of Stimulant Choice
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 15 Apr 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20265-HT Agonists5-Hydroxytryptamine Agonists5-Hydroxytrytamine AgonistAccelerationAcetylcholine AgonistsAcetylcholine Receptor, Muscarinic 1AdmissionAdmission activityAgonistAnimalsAssayAttenuatedBasic ResearchBasic ScienceBehaviorBehavioralBioassayBiological AssayBiosensorCHRM1CHRM1 geneCell Communication and SignalingCell SignalingCessation of lifeChemical DependenceCholinergic AgonistsCholinergic Receptor, Muscarinic 1ClinicalClinical DataClinical TrialsCocaineCocaine AbuseCocaine use disorderCommon Rat StrainsCrystal MethCrystal methamphetamineDataDeathDecision MakingDeoxyephedrineDesoxyephedrineDevelopmentDopamineDoseDrug AddictionDrug DependenceDrug DependencyDrug TherapyDrug Use DisorderDrugsEffectivenessExperimental DesignsFailureFemaleFoodFood PreferencesFood and Drug AdministrationFundingHumanHydroxytyramineIntracellular Communication and SignalingLaboratory AnimalsLaboratory StudyMeasuresMediatorMedicationMethamphetamineMethamphetamine use disorderMethylamphetamineMicrodialysisModelingModern ManMonitorMuscarinic Acetylcholine ReceptorMuscarinic AgentsMuscarinic ReceptorsMuscarinicsN-MethylamphetamineNIDANational Institute of Drug AbuseNational Institute on Drug AbuseNational Institutes of HealthNegative ReinforcementsNerve Transmitter SubstancesNeurobiologyNeurotransmittersNucleus AccumbensPharmaceutical PreparationsPharmacological TreatmentPharmacologyPharmacotherapyPreclinical dataPrefrontal CortexProceduresPublic HealthPublicationsRatRats MammalsRattusResearchResearch SubjectsScientific PublicationSelf AdministeredSelf AdministrationSeriesSerotonergic AgonistsSerotonin AgonistsSerotonin Receptor AgonistsSignal TransductionSignal Transduction SystemsSignalingSourceStimulantSystemTestingTimeUSFDAUnited States Food and Drug AdministrationUnited States National Institutes of HealthWorkantagonismantagonistassess effectivenessattenuateattenuatesbiological sensorbiological signal transductiondetermine effectivenessdevelopmentaldiet choicediet preferencedietary choicedietary preferencesdrug interventiondrug treatmentdrug/agenteffectiveness assessmenteffectiveness evaluationevaluate effectivenessexamine effectivenessexperimentexperimental researchexperimental studyexperimentsfood choicehuman subjectin vivomalemethmeth abusemeth use disordermethamphetamine abuseneurobiologicalnon-drugnondrugoverdose deathoverdose fatalitiespharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinicalpreclinicalpreclinical findingspreclinical informationpsychostimulant abusepsychostimulant misusepsychostimulant use disorderreinforcersocialstimulant abusestimulant misusestimulant use disordertherapeutic candidate♀♂
Description preview
This new R01 application proposes a systematic series of experiments focused on drug-choice procedures in
male and female rats to evaluate the muscarinic acetylcholine receptor (mAChR)1 agonist VU0364572 as a
candidate medication for treatment of cocaine and methamphetamine use disorder. This application is founded
on the premise that stimulant…
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