grant
Pharmacokinetic and pharmacodynamic relationships for antibacterial treatment of shigellosis
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 6 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20260-11 years oldAccelerationAcuteAfricaAlimentary CanalAnimal ExperimentsAnti-Bacterial AgentsAreaAsiaAzadoseAzithromycinAzitrocinAzythromycinBacillary DysenteryBacterial Drug ResistanceBlood PlasmaCefiximeCell LineCellLineCessation of lifeCharacteristicsChildChild YouthChildren (0-21)CiprofloxacinClinicClinicalColonCommunicable DiseasesCommunitiesCountryCryptosporidiosisCryptosporidiumCryptosporidium infectionDataDeathDevelopmentDiarrheaDigestive TractDoseDose FractionationDrug ExposureDrug KineticsDrug resistanceDrugsDysenteryEnteralEntericEnvironmentFatty AcidsFiberFoundationsFutureGI TractGastrointestinal AgentsGastrointestinal DrugsGastrointestinal TractGastrointestinal tract structureGeneralized GrowthGoalsGrowthHumanIn VitroInfectionInfectious Diarrheal DiseaseInfectious DiseasesInfectious DisorderInvadedKnowledgeLarge IntestineLinkLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMSMMan who have sex with ManMedicationMethodsMiceMice MammalsModelingModern ManMulti-center studiesMulticenter StudiesMurineMusOral AdministrationOral Drug AdministrationPBPKPK/PDPharmaceutical PreparationsPharmacodynamicsPharmacokineticsPhysiologicPhysiologicalPlasmaPlasma SerumPopulation Attributable RisksPreclinical dataPrevalencePropertyRadiotherapy Dose FractionationRationalizationRecommendationReducing AgentsReductantsRegimenReportingResearchResearch ResourcesResistanceResistance developmentResistant developmentResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingResourcesReticuloendothelial System, Serum, PlasmaSeriesShigellaShigella DysenteryShigella InfectionsSiteStrains Cell LinesSymptomsTherapeuticTherapeutic EffectTimeTissue GrowthToxic effectToxicitiesUltreonVirulenceWorkZithromaxZitromaxalimentary tractanimal experimentanti-bacterialanti-bacterial drug resistanceanti-bacterial drug resistantanti-bacterial resistanceanti-bacterial resistantattributable fractionbile saltsburden of diseaseburden of illnesscultured cell linedesigndesigningdeveloping resistancedevelopmentaldiarrheal diseasediarrheal illnessdigestive canaldisease burdendrug developmentdrug discoverydrug resistantdrug/agententeral infectionenteral pathogenenteric infectionenteric pathogenenteric pathogen infectionenteropathogenenteropathogen infectionenteropathogenic infectionexperimental animalexperimental animalsgastrointestinalimaging mass spectrometryimprovedin vivoin vivo Modelindexinginfected with Cryptosporidiuminfected with enteropathogeninnovateinnovationinnovativeintestinal infectionintestinal pathogenintestine infectionintestine pathogenintraoral drug deliverykidslarge bowelmass spectrometric imagingmen having sex with menmen who have sex with menmen who have sex with other menmortalitymouse modelmurine modelnew chemical entitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypathogenpharmacodynamic modelpharmacokinetic modelpharmacokinetics and pharmacodynamicsphysiologically based pharmacokineticspre-clinicalpre-clinical developmentpreclinicalpreclinical developmentpreclinical findingspreclinical informationresistance strainresistance to Drugresistance to anti-bacterialresistantresistant strainresistant to Drugresistant to anti-bacterialresponseshigellosistoolyoungster
Description preview
Project Summary/Abstract
Enteric infection with Shigella spp. can lead to symptoms ranging from acute watery diarrhea to sudden,
severe dysentery. Approximately 212,000 diarrheal deaths annually are attributed to Shigella (12.5% of total
diarrheal deaths) with a disproportionate impact in low resource countries. The impact in low resource…
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