grant
pH-Dependent Switching of ESX-1 Substrates in Mycobacterial Pathogenesis
Organization UNIVERSITY OF NOTRE DAMELocation NOTRE DAME, UNITED STATESPosted 12 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAnimalsApproaches to preventionAssayAttenuatedBioassayBiological AssayBiologyBlood erythrocyteCell BodyCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelChaperoneChemicalsCollectionCuesCytolysisCytoplasmDataDiagnosisDiseaseDisorderELF3ELF3 geneEPR-1ERT geneERT proteinESE-1ESXEnvironmentErythrocytesErythrocyticGene TranscriptionGenesGeneticGenetic TranscriptionGenus MycobacteriumGoalsHealthHemolysisHumanImmuneImmune Cell ActivationImmune PrecipitationImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunoprecipitationIn VitroInfectionLong-term infectionLysisLysosomesLyticM marinumM tbM tuberculosisM tuberculosis infectionM. marinumM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacrophageMacrophage ActivationMarrow erythrocyteMating Type Switch 1MeasuresMembraneMissionModelingModern ManMolecularMolecular ChaperonesMolecular GeneticsMycobacterial InfectionMycobacteriumMycobacterium InfectionsMycobacterium marinumMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNational Institutes of HealthPathogenesisPathogenicityPhagocytesPhagocytic CellPhagosomesPhysiologyPreventionPrevention approachProtein SecretionProteinsProteomeProteomicsPublic HealthQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNA ExpressionRed Blood CellsRed CellResearchRestSWI1SeminalStudy modelsSubcellular ProcessSwi1/Adr6Switch 1SystemTB infectionTB therapyTB treatmentTestingTranscriptionTuberculosisUnited States National Institutes of HealthVirulenceWorkacute infectionamebocyteattenuateattenuatesblood corpuscleschronic infectiondisseminated TBdisseminated tuberculosiserythrolysisgenetic approachgenetic strategyimmune activationimprovedinfection due to Mycobacterium tuberculosisinhibitorinnovateinnovationinnovativeinsightmembrane structuremodel of animalmtbmycobacterialnew approachesnovel approachesnovel strategiesnovel strategypandemicpandemic diseasepathogenpersistent infectionqRTPCRresponsetreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathy
Description preview
PROJECT SUMMARY
Pathogenic mycobacteria, including Mycobacterium tuberculosis, cause acute and chronic infections that significantly im-
pact human health. Mycobacterium marinum is a non-tubercular mycobacterial pathogen and a well-established model for
studying several aspects of M. tuberculosis pathogenesis, including ESX-1 secretion. Early…
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