grant
PFAS induced alterations in reward processing
Organization PURDUE UNIVERSITYLocation WEST LAFAYETTE, UNITED STATESPosted 1 Jan 2024Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202618 year old18 years of age21+ years oldActive Follow-upAdultAdult HumanAmphibiaAmphibiansAnhedoniaAnimal ExperimentsAnimal ModelAnimal Models and Related StudiesAnimalsAreaBehavioralBiochemicalBloodBlood Reticuloendothelial SystemBlood SerumBrainBrain Nervous SystemBrain regionCausalityClinicalCommunitiesCross-Sectional StudiesCross-Sectional SurveyDataDevelopmentDevelopmental ToxicantDiseaseDisease Frequency SurveysDisorderDoseEmotional DepressionEncephalonEnvironmentEnvironmental ExposureEnvironmental PollutantsEtiologyExperimental DesignsExposure toFoundationsFutureHealthHistoryHumanIndianaIndividualLaboratoriesLaboratory AnimalsLaboratory miceLifeLightLinkLiteratureLongitudinal StudiesLongitudinal SurveysMajor Depressive DisorderManiasManicManic StateMeasurementMeasuresMediatingMental DepressionMental disordersMental health disordersMiceMice MammalsModelingModern ManMolecularMonitorMurineMusNematodaNematodesNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNervous System DiseasesNervous System DisorderNeurologicNeurologic DisordersNeurologicalNeurological DisordersNeuronal TransmissionNeurotransmittersOnset of illnessOutcomePFASPatient Self-ReportPhenotypePhotoradiationPoly-fluoroalkyl substancesPsychiatric DiseasePsychiatric DisorderPsychosesPublic HealthPublishingRecording of previous eventsRegimenResearchRewardsRiskRoleSamplingSelf-ReportSentinelSerumSeveritiesSpecificitySystemTestingTimeTranslationsVentral StriatumWeaningWild Animalsactive followupadulthoodage 18age 18 yearsanimal dataanimal experimentaxon signalingaxon-glial signalingaxonal signalingbehavior phenotypebehavioral phenotypingbrain tissuecausationclinical depressionclinical phenotypeclinical relevanceclinical translationclinically relevantclinically translatablecross-sectional research studydata modelingdepressiondepression symptomdepressivedepressive symptomsdevelopmentaldevelopmental neurotoxicitydisease causationdisease onsetdisorder onsetearly life exposureeighteen year oldeighteen years of ageenvironmental contaminantexperimental animalexperimental animalsexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesflexibilityflexiblefollow upfollow-upfollowed upfollowupglia signalingglial signalinghistorieshuman datahuman studyinnovateinnovationinnovativelong-term studylongitudinal outcome studieslongitudinal research studymajor depressionmajor depression disordermental illnessmodel of animalmodel of datamodel the datamodeling of the datamouse modelmurine modelnerve signalingneuralneural signalingneurobehavioralneurochemicalneurochemistryneurological diseaseneuron toxicityneuronal signalingneuronal toxicityneuropathologicneuropathologicalneuropathologyneurophysiologicalneurophysiologyneuropsychiatric diseaseneuropsychiatric disorderneurotoxicneurotoxicityneurotransmissionperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancespolyfluorinated alkyl substancespolyfluoroalkyl substancespsychiatric illnesspsychiatric symptompsychological disorderreward processingroundwormsocial rolestemtranslationtranslation strategytranslational approachtranslational strategy
Description preview
Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants that have been
investigated as developmental toxicants, with little information on long-term neurotoxicity and clinical
outcomes. Our preliminary data suggest that PFAS may produce neurotransmission changes relevant to
psychiatric disorders involving abnormal…
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