grant
PFAS induced alterations in reward processing
Organization PURDUE UNIVERSITYLocation WEST LAFAYETTE, UNITED STATESPosted 1 Jan 2024Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202521+ years oldActive Follow-upAdultAdult HumanAmphibiaAmphibiansAnhedoniaAnimal ExperimentsAnimal ModelAnimal Models and Related StudiesAnimalsAreaBehavioralBiochemicalBloodBlood Reticuloendothelial SystemBlood SerumBrainBrain Nervous SystemBrain regionCausalityClinicalCommunitiesCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataDevelopmentDevelopmental ToxicantDiseaseDisease Frequency SurveysDisorderDoseEmotional DepressionEncephalonEnvironmentEnvironmental ExposureEnvironmental PollutantsEtiologyExperimental DesignsExposure toFoundationsFutureHealthHistoryHumanIndianaIndividualLaboratoriesLaboratory AnimalsLaboratory miceLifeLightLinkLiteratureLongitudinal StudiesMajor Depressive DisorderManiasManicManic StateMeasurementMeasuresMediatingMental DepressionMental disordersMental health disordersMiceMice MammalsModelingModern ManMolecularMonitorMurineMusNematodaNematodesNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNervous System DiseasesNervous System DisorderNeurologicNeurologic DisordersNeurologicalNeurological DisordersNeuronal TransmissionNeurotransmittersOnset of illnessOutcomePFASPatient Self-ReportPhenotypePhotoradiationPoly-fluoroalkyl substancesPsychiatric DiseasePsychiatric DisorderPsychosesPublic HealthPublishingRecording of previous eventsRegimenResearchRewardsRiskRoleSamplingSelf-ReportSentinelSerumSeveritiesSpecificitySystemTestingTimeTranslationsVentral StriatumWeaningWild Animalsactive followupadulthoodagedanimal dataanimal experimentaxon signalingaxon-glial signalingaxonal signalingbehavior phenotypebehavioral phenotypingbrain tissuecausationclinical depressionclinical phenotypeclinical relevanceclinical translationclinically relevantclinically translatabledata modelingdepressiondepression symptomdepressivedepressive symptomsdevelopmentaldevelopmental neurotoxicitydisease causationdisease onsetdisorder onsetearly life exposureenvironmental contaminantexperimental animalexperimental animalsflexibilityflexiblefollow upfollow-upfollowed upfollowupglia signalingglial signalinghistorieshuman datahuman studyinnovateinnovationinnovativelong-term studylongitudinal outcome studiesmajor depressionmajor depression disordermental illnessmodel of animalmodel of datamodel the datamodeling of the datamouse modelmurine modelnerve signalingneuralneural signalingneurobehavioralneurochemicalneurochemistryneurological diseaseneuron toxicityneuronal signalingneuronal toxicityneuropathologicneuropathologicalneuropathologyneurophysiologicalneurophysiologyneuropsychiatric diseaseneuropsychiatric disorderneurotoxicneurotoxicityneurotransmissionperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancespolyfluorinated alkyl substancespolyfluoroalkyl substancespsychiatric illnesspsychiatric symptompsychological disorderreward processingroundwormsocial rolestemtranslationtranslation strategytranslational approachtranslational strategy
Description preview
Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants that have been
investigated as developmental toxicants, with little information on long-term neurotoxicity and clinical
outcomes. Our preliminary data suggest that PFAS may produce neurotransmission changes relevant to
psychiatric disorders involving abnormal…
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