grant
PET Imaging of Renal Fibrosis
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 20 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20251H-Purin-6-amine21+ years oldAbbreviationsAccelerationAdenineAdultAdult HumanAffectAgingAllograftingAlport syndromeAlport syndrome (AS, ATS)Alport syndrome-like hereditary nephritisAlport syndrome-like hereditary nephritis (ASLHN, ASLN)Alport's SyndromeAmino AcidsAngiotensin Converting EnzymeAngiotensin I-Converting EnzymeAnimal ModelAnimal Models and Related StudiesBindingBiochemicalBiodistributionBiological MarkersBiopsyBiopsy SampleBiopsy SpecimenBlood PlasmaBlood SampleBlood SerumBlood specimenBody TissuesCD143 AntigensCarboxycathepsinCardiovascular DiseasesCausalityChronicChronic Allograft NephropathyChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureChronic rejection of renal transplantCicatrixClinicalClinical TrialsCollagenCollagen Lysyl OxidaseCommon Rat StrainsCreatinineDialysisDialysis procedureDickinson syndromeDietDipeptidyl Peptidase ADiseaseDisorderDrug KineticsDysfunctionEC 1.4.3.13ESKDESRDEarly DiagnosisEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEnzyme GeneEnzyme InhibitionEnzymesEtiologyFamilial NephritisFibrosisFunctional disorderGoalsGraft RejectionGraft SurvivalHPLCHereditary nephritisHigh Performance Liquid ChromatographyHigh Pressure Liquid ChromatographyHigh Speed Liquid ChromatographyHistologicHistologicallyHumanInflammationInjectionsIonsIschemia-Reperfusion InjuryKidneyKidney GraftingKidney Replacement TherapyKidney TransplantationKidney TransplantsKidney Urinary SystemKininase AKininase IILabelLibrariesLysyl OxidaseMR ImagingMR TomographyMRIMRIsMacacaMacaqueMagnetic ResonanceMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetalsMiceMice MammalsModelingModern ManMolecular InteractionMonitorMonkeysMurineMusNHP modelsNMR ImagingNMR TomographyNatural HistoryNephritisNephrotoxicNon-Invasive DetectionNoninvasive DetectionNuclear Magnetic Resonance ImagingOutputPETPET ScanPET imagingPETSCANPETTPathologyPathway interactionsPatientsPeptidyl-Dipeptidase APharmacokineticsPhysiopathologyPlasmaPlasma SerumPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredictive ValueProcessPrognostic MarkerProtein-Lysine 6-OxidaseProtocolProtocols documentationPublic HealthRad.-PETRadiation DosimetryRadiolabeledRadiometryRatRats MammalsRattusRecoveryRenal GraftingRenal Replacement TherapyRenal TissueRenal TransplantationRenal TransplantsRenal functionReperfusion DamageReperfusion InjuryReportingResearchResidenciesReticuloendothelial System, Serum, PlasmaRiskRodent ModelSafetySamplingSampling ErrorsScanningScarsSerumSurrogate End PointsSurrogate EndpointTechnologyTimeTissue DonorsTissuesToxic effectToxicitiesToxicologyTranslationsTransplant RecipientsTransplant RejectionTransplantationTransplantation RejectionVitamin B4Zeugmatographyadulthoodaminoacidanalytical methodantibody rejectionantibody-mediated rejectionbio-markersbiologic markerbiomarkercardiovascular disordercardiovascular riskcardiovascular risk factorcausationchronic kidney diseaseclinical translationclinically translatablecongenital hereditary hematuriacrosslinkdeafness-nephritis syndromediagnostic tooldialysis therapydietsdisease causationdosimetry imagingearly detectionfibrogenesisgood laboratory practicehearing loss-nephritis syndromehematuria-nephropathy-deafness syndromehematuric familial nephropathyhematuric hereditary nephritishemorrhagic familial nephritishemorrhagic hereditary nephritishereditary familial congenital hemorrhagic nephritishereditary hematuria syndromehereditary interstitial pyelonephritishereditary nephritis-deafness syndromehereditary nephritis-deafness-abnormal thrombogenesis syndromehigh riskimage-based methodimaging methodimaging modalityimaging probeinterstitialkidney biopsykidney fibrosiskidney functionkidney imagingkidney ischemiakidney toxicitykidney txmanufacturemanufacturing processmodel of animalmouse modelmurine modelnephrotoxicitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-human primatenon-invasive imagingnonhuman primatenonhuman primate modelsnoninvasive imagingnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologypathwaypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredict clinical outcomepreventpreventingprognostic biomarkerprognostic indicatorprogramsradioassayradiolabelingradiologically labeledrenalrenal biopsyrenal fibrosisrenal ischemiaresponseresponse to therapyresponse to treatmentsuccesstherapeutic responsetherapy responsetooltranslationtransplanttransplant patienttreatment responsetreatment responsivenessuptake
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Project Summary
Chronic kidney disease (CKD) is the most under-recognized public health issue in the US affecting more
than 35 million adults and it is projected that 47% of 30-year-olds will develop CKD in their lifetime. CKD is also
one of the strongest risk factors for cardiovascular disease. Treatments to slow progression are limited and…
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