grant
PET imaging of dynorphin/kappa-opioid reactivity to stress in depression
Organization NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INCLocation NEW YORK, UNITED STATESPosted 15 Sept 2022Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2023AccelerationActive Follow-upAddictive BehaviorAdrenal GlandsAdrenalsAeroseb-HCAffective DisordersAgonistAnhedoniaAnteriorAnxietyAutopsyAwardBiologicalBiologyBiomedical EngineeringBrainBrain Nervous SystemBrain imagingBrain regionBrain scanCell PhoneCellular PhoneCellular TelephoneCetacortCharacteristicsClinicCort-DomeCortefCortenemaCortisolCortisprayCortrilDSM-5DSM-VDSM5Depressed moodDermacortDevelopmentDiagnosisDiagnostic and Statistical Manual of Mental Disorders, 5th editionDiagnostic and Statistical Manual of Mental Disorders-VDisease remissionDrug TargetingDynorphinsDysfunctionEcological momentary assessmentEldecortEmotional DepressionEncephalonExhibitsFunctional disorderGoalsHPA axisHumanHydrocortisoneHydrocortoneHypophysisHypophysis CerebriHypothalamic structureHypothalamusHytoneImageIndividualInterventionIntervention StrategiesLaboratoriesLifeLife StressLinkMR ImagingMR TomographyMRIMRI ScansMRIsMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMajor Depressive DisorderMeasurableMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionMental disordersMental health disordersMobile PhonesModern ManMood DisordersNMR ImagingNMR TomographyNeurobiologyNuclear Magnetic Resonance ImagingNutracortOpioid Receptor BindingOutcome StudyPETPET ScanPET imagingPETSCANPETTParticipantPathogenesisPeripheralPhysiologicPhysiologicalPhysiopathologyPilot ProjectsPituitaryPituitary GlandPituitary Nervous SystemPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrincipal InvestigatorProcessProctocortPsychiatric DiseasePsychiatric DisorderRad.-PETRegulationRemissionReportingResearchRestRodentRodentiaRodents MammalsRoleSensitivity and SpecificitySeveritiesSingle major depressionSingle major depressive episodeStandardizationStressStructureTestingThickThicknessTracerTrainingTransmissionWorkZeugmatographyactive followupbio-engineeredbio-engineersbioengineeringbiologicbiological adaptation to stressbiological engineeringbrain visualizationclinical depressiondepresseddepressiondepression symptomdepressivedepressive symptomsdesigndesigningdevelopmentaldisabilitydrug developmentdysphoriaefficacious therapyefficacious treatmentfollow upfollow-upfollowed upfollowuphypothalamichypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisiPhoneimagingimprovedin vivoin vivo monitoringinnovateinnovationinnovativeinterventional strategyinvestigator trainingkappa opiatekappa opioidkappa opioid receptorsmajor depressionmajor depression disordermajor depressive episodemental illnessmulti-modal neuro-imagingmulti-modal neuroimagingmultimodal neuro-imagingmultimodal neuroimagingnecropsyneuralneural correlateneurobiologicalneurobiological mechanismpathophysiologypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpilot studypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortempre-clinicalpreclinicalprogramsprospectivepsychiatric illnesspsychologicpsychologicalpsychological disorderreaction; crisisresearch studyresponsesadnesssingle episode Major Depressionsingle episode major depressive disorderskillssmart phonesmartphonesocialsocial rolestress reactivitystress responsestress; reactionstressorsuprarenal glandsymptomatologytherapeutic targettraittransmission processκ opiateκ opioidκ opioid receptorsκ-ORκOR
Description preview
PROJECT SUMMARY/ABSTRACT: Major depressive disorder (MDD) is a leading cause of disability worldwide
with a paucity of personalized, efficacious treatments. Life stressors have long been shown to potently predict
depressive symptomatology and onset of major depressive episodes. Despite this, the neurobiological
mechanisms underlying stress…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click