grant
PET Biomarker for synaptic density changes after radiation therapy
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 3 Sept 2024Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAcquired brain injuryAddressAdultAdult HumanAmmon HornAnatomic SitesAnatomic structuresAnatomyAxonBehavioralBiological MarkersBrainBrain InjuriesBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsBrain regionCNS Nervous SystemCancersCellular injuryCentral Nervous SystemChildChild YouthChildren (0-21)Clinical TrialsCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCommon Rat StrainsComplicationContralateralCornu AmmonisCranial IrradiationDegenerative Neurologic DisordersDevelopmentDisturbance in cognitionDrugsEarly DiagnosisEarly InterventionEncephalonEndothelial CellsEpilepsyEpileptic SeizuresEpilepticsEvaluationFutureGlioblastomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHippocampusHumanImageImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpaired cognitionImplantIn VitroLabelLifeMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant NeoplasmsMalignant TumorMapsMeasurementMeasuresMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMethodsModelingModern ManMolecularMonitorNMR ImagingNMR TomographyNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurological DamageNeurological InjuryNeurological traumaNeuronsNuclear Magnetic Resonance ImagingOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOperative ProceduresOperative Surgical ProceduresPETPET ScanPET imagingPETSCANPETTPathologicPatientsPharmaceutical PreparationsPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrefrontal CortexProcessProteinsRad.-PETRadiationRadiation ChemistryRadiation OncologyRadiation induced damageRadiation therapyRadiochemistryRadiotherapeuticsRadiotherapyRatRats MammalsRattusRodentRodentiaRodents MammalsScanningSeizure DisorderSideSurgicalSurgical InterventionsSurgical ProcedureSynapsesSynapticSynaptic VesiclesTimeTracerTranslatingTreatment ProtocolsTreatment RegimenTreatment ScheduleTreatment Side EffectsTreatment-related side effectsWestern BlottingWestern ImmunoblottingZeugmatographyadulthoodaxon damageaxon injuryaxonal damageaxonal injurybio-markersbiologic markerbiomarkerbrain damagebrain irradiationbrain radiationbrain-injuredcell damagecell injurycellular damagechemotherapyclinical practiceclinical translationclinically translatablecognitive assessmentcognitive changecognitive defectscognitive dysfunctioncognitive functioncognitive losscognitive testingcranial radiationdamage to cellsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdensitydevelopmentaldrug/agentearly biomarkersearly detectionearly detection biomarkersearly detection markersepilepsiaepileptogenicglioblastoma multiformegray matterhippocampalimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerinjury to cellsinsightkidslongitudinal imagingmalignancyneoplasm/cancerneural inflammationneurocognitive testneurodegenerative illnessneuroinflammationneuroinflammatoryneuronalneuropathologicneuropathologicalneuropathologyneurosurgeryneurotraumanovelpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreservationpresynapticpreventpreventingprotein biomarkersprotein blottingprotein markersradiation damageradiation treatmentresponseserial imagingspongioblastoma multiformestandard of caresubstantia albasubstantia griseasurgerysynapsetimelinetooltreatment with radiationtumortumors in the brainwhite matterwhite matter changewhite matter damageyoungster
Description preview
Project Summary/Abstract: Whole brain synaptic density imaging with quantitative positron emission
tomography (PET) has demonstrated critical insights into understanding of neurodegenerative disorders and
epilepsy, especially in the setting of normal anatomical MRI. We propose to use quantitative whole brain PET
with a novel synaptic density…
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