grant
Persistent Immunogenicity of IDLV delivering Gag and membrane tethered HIV-1 Envelope Trimers
NIHUS FederalResearch GrantFY20252019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike proteinAIDS VirusAb responseAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAffinityAnimalsAntibody FormationAntibody ProductionAntibody ResponseAntigensAssayAutologousAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellB-cell receptor repertoire sequencingB-cell receptor sequencingBCR repertoire sequencingBCR seqBCR sequencingBCRseqBMCELLTYBindingBioassayBiologic ModelsBiological AssayBiological ModelsBloodBlood Plasma CellBlood Reticuloendothelial SystemBlood SampleBlood specimenBone MarrowBone Marrow AspirationBone Marrow CellularityBone Marrow Reticuloendothelial SystemCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID-19 S proteinCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCell BodyCell LineageCellsClinicClinical Treatment MoabClonal ExpansionDNADNA mutationDataDeoxyribonucleic AcidDevelopmentFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesGametesGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGerm CellsGerm-Line CellsGerminal CenterGoalsGrowthHIVHIV envelopeHIV envelope proteinHIV vaccineHIV-1HIV-1 vaccineHIV-IHIV/AIDS VaccinesHIV1HIV1 vaccineHealth PrioritiesHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1ImmuneImmune responseImmunesImmunizationImmunizeIndividualInfectionIntegraseKineticsLAV-HTLV-IIILengthLentiviral VectorLentivirus VectorLymph Node Reticuloendothelial SystemLymph node properLymphadenopathy-Associated VirusLymphatic nodesM mulattaM. mulattaMacaca mulattaMacaca rhesusMembraneMessenger RNAMiceMice MammalsModalityModel SystemModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonoclonal AntibodiesMucosaMucosal TissueMucous MembraneMurineMusMutationPassive ImmunotherapyPatternPersonsPlasma CellsPlasmacytesPreventative vaccinePreventionPreventive vaccineProphylactic vaccineProteinsRegimenReproductive CellsRetroviral Antigen gag ProteinRhesus MacaqueRhesus MonkeySARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSHIVSIVSamplingSevere acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSex CellSimian Immunodeficiency VirusesStructure of germinal center of lymph nodeT cell responseT-CellsT-LymphocyteT8 CellsT8 LymphocytesTeff cellTestingTimeTissue GrowthTranslationsTransmissionVaccinatedVaccinationVaccine AntigenVaccinesViral DiseasesViral gag ProteinsVirusVirus DiseasesVirus-HIVantibody biosynthesischallenge in rhesus macaquesconformationconformationalconformational stateconformationallyconformationscoronavirus disease 2019 S proteincoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteindeliver vaccinesdevelopmentaldrivingeffector T cellefficacy studyexpression vectorflow cytophotometrygag Antigensgag Gene Productsgag Polyproteinsgag Proteingenome mutationglobal healthgroup specific antigenhost responsehuman immunodeficiency virus vaccineimmune response to vaccinationimmune response to vaccinesimmune system responseimmunization strategyimmunogenimmunogenicityimmunoglobulin biosynthesisimmunoresponseinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinitial cellinsightlymph glandlymph node biopsylymph nodeslymphnodesmAbsmRNAmembrane structuremonoclonal Absneutralizing antibodynon-human primatenonhuman primatenovelontogenypandemicpandemic diseasepassive immune therapypassive immunotherapeuticsperipheral bloodplasmid vaccineplasmocytepreventpreventingresponserhesus challengerhesus macaque challengerhesus monkey infectionsexual cellsimian HIVsimian human immunodeficiency virusspike proteins on SARS-CoV-2therapeutic vaccinethymus derived lymphocytetranscriptomicstranslationtransmission processtreatment vaccinesvaccination strategyvaccine associated immune responsevaccine deliveryvaccine efficacyvaccine for the treatmentvaccine for treatmentvaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine platformvaccine responsevaccine responsivenessvaccine-induced responsevectorvector inducedvector vaccineviral infectionvirus infectionvirus-induced disease
Description preview
ABSTRACT
Halting the spread of HIV-1 infection with a protective vaccine continues to be a global health priority.
Passive immunotherapy with broadly neutralizing antibodies (bnAbs), and vaccine-induced autologous
tier 2 nAbs, have proven effective in preventing simian-human immunodeficiency virus (SHIV) infection
in non-human primates (NHPs).…
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