grant

Persistence and Evolution of SARS-CoV-2

NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAnatomic SitesAnatomic structuresAnatomyB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBloodBlood Reticuloendothelial SystemBody TissuesCOVID-19COVID-19 genomeCOVID-19 virusCOVID-19 virus genomeCOVID19 genomeCOVID19 virusCOVID19 virus genomeCV-19Cell IsolationCell SegregationCell SeparationCell Separation TechnologyClinicalCoV-2CoV2Confocal MicroscopyCoronavirus Infectious Disease 2019DNA mutationDiseaseDisorderEvolutionGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationImageImage CytometryImmune responseImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualLaboratoriesLower respiratory tract structureLymphoid CellMemory B CellMemory B-LymphocyteMolecular AnalysisMutationMyeloid CellsNon-Polyadenylated RNAOutcomePBMCPeripheral Blood Mononuclear CellPersonsPopulationPrevalenceRNARNA Gene ProductsRT-PCRReverse Transcriptase Polymerase Chain ReactionRibonucleic AcidSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 genomeSARS-CoV2SARS-CoV2 genomeSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SEQ-ANSamplingSequence AnalysesSequence AnalysisSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SiteT cell responseTestingTissue SampleTissuesUpper respiratory tractViral GeneticsVirusWuhan coronavirusacute COVID-19acute SARS-CoV-2 infectionacute phase of COVID-19acute phase of SARS-CoV-2 infectioncell sortingcell typecoronavirus disease 2019coronavirus disease 2019 genomecoronavirus disease 2019 viruscoronavirus disease 2019 virus genomecoronavirus disease-19coronavirus disease-19 viruscoronavirus infectious disease-19deep sequencinggenome mutationhCoV19host responseimagingimmune system responseimmunoresponsein vivolower respiratory tractnCoV2respiratoryreverse transcriptase PCRsevere acute respiratory syndrome coronavirus 2 genomesingle moleculestemupper airway tractvirus genetics
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The levels of SARS-CoV-2 replication in vivo, the virus genetic variation arising through this replication, and the distribution of the virus among distinct cell types and tissues may help determine the clinical outcome of acute COVID-19 as well as the long-term protective capacity of virus-specific memory B and T cell responses. The weeks-long…

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