grant
Peripheral Biomarkers for Early Diagnosis of Mixed Pathologies in AD/ADRD
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 1 Jun 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDActive Follow-upAffectAgeAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's diagnosisAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease diagnosisAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's patientAlzheimers DementiaAmentiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAssayAutopsyAβBioassayBiological AssayBiological MarkersBiopsyBiopsy SampleBiopsy SpecimenBrainBrain Nervous SystemBrain imagingCadaverClinicClinicalCollectionConsensusCorticodentatonigral degeneration with neuronal achromasiaDementiaDementia with Lewy BodiesDepositDepositionDermatologic biopsyDetectionDevelopmentDiagnosisDiagnostic testsDifferential DiagnosisDiseaseDisease ProgressionDisorderEarly DiagnosisEmergent TechnologiesEmerging TechnologiesEncephalonGoalsImmunoassayLB dementiaLewy Body DementiaLewy Body Type Senile DementiaLewy dementiaMT-bound tauMeasuresMemoryNAC precursorOutcomeOutcome StudyPARK1 proteinPARK4 proteinPD with dementiaParalysis AgitansParkinsonParkinson DiseaseParkinson Disease dementiaParkinson's DementiaParkinson's disease with dementiaParticipantPathologicPathologyPatient CarePatient Care DeliveryPatientsPeripheralPersonsPositionPositioning AttributePrimary ParkinsonismPrimary Senile Degenerative DementiaProbabilityProgressive Supranuclear OphthalmoplegiaProgressive Supranuclear PalsyRegistriesResearchResearch ResourcesResearch SpecimenResourcesSNCASNCA proteinSamplingSeverity of illnessSkinSpecimenSteele-Richardson-Olszewski DiseaseSteele-Richardson-Olszewski SyndromeSymptomsTauopathiesTestingTimeValidationVisita beta peptidea-syna-synucleinabetaabnormally aggregated tau proteinaccurate diagnosisactive followupagesalpha synucleinalpha synuclein genealphaSP22amyloid betaamyloid-b proteinasynbeta amyloid fibrilbio-markersbiobankbiologic markerbiomarkerbiorepositorybrain tissuebrain visualizationcadavericcadaverscare for patientscare of patientscaring for patientsclinical diagnosisclinical practiceco-morbidco-morbiditycomorbiditycortical basal degenerationcortico-basal syndromecorticobasal degenerationcorticobasal syndromecutaneous biopsydementia in PDdementia in Parkinson diseasedevelopmentaldiagnostic assaydiagnostic biomarkerdiagnostic markerdiagnostic tooldisease durationdisease lengthdisease severityearly biomarkersearly detectionearly detection biomarkersearly detection markersfilamentous tau inclusionfollow upfollow-upfollowed upfollowupillness lengthimprovedinsoluble aggregatemicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taunecropsyneuropathologicneuropathologic tauneuropathologicalneuropathological tauneuropathologynew markernew technologynon A-beta component of AD amyloidnon A4 component of amyloid precursornovel biomarkernovel markernovel technologiesp-taup-τpaired helical filament of taupatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasephospho-tauphospho-τphosphorylated taupost-translational modification of taupostmortemposttranslational modification of tauprimary degenerative dementiaprion-likeprospectiveprotein aggregateprotein aggregationrecruitself-aggregate tausenile dementia of the Alzheimer typesexskin biopsysoluble amyloid precursor proteinsuccesssynucleinopathytautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau fibrillizationtau filamenttau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neurofibrillary tangletau neuropathologytau oligomertau paired helical filamenttau pathologytau pathophysiologytau phosphorylationtau polymerizationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytau-tau interactiontauopathic neurodegenerative disordertauopathytherapeutic agent developmenttherapeutic developmentvalidationsα synuclein geneα-synα-synucleinτ Proteinsτ aggregationτ phosphorylation
Description preview
The overall goal of our proposed research is to develop robust premortem biomarkers for accurate and
differential diagnosis of Alzheimer's disease (AD), non-AD tauopathies, Lewy body dementia (LBD), and their
comorbidities. A pathological hallmark of AD and other tauopathies is the deposition of tau protein aggregates
in the brain, whereas in LBD…
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