grant
Perinatal PFAS Impact Children's Development: Examining the Roles of Placental Functional Multiomics and Protection by Maternal Exercise
Organization ARKANSAS CHILDREN'S HOSPITAL RES INSTLocation LITTLE ROCK, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20260-11 years old0-4 weeks old5 year old5 years of ageActive Follow-upAddressAdverse effectsAge MonthsAttenuatedBiologicalBirthBlood SerumBody SystemBody WeightBody fatCarbonCells Placenta-TissueChemicalsChildChild DevelopmentChild HealthChild YouthChildren (0-21)Chronic DiseaseChronic IllnessCohort AnalysesCohort AnalysisCommunitiesDNADataDeoxyribonucleic AcidDevelopmentDiseaseDisorderDysfunctionEnvironmental ExposureEnvironmental PollutantsExerciseExposure toF elementFamilyFluorineFunctional disorderFundingFutureFuture GenerationsGeneralized GrowthGenesGestationGrowthGrowth and DevelopmentGrowth and Development functionHealthHistoryIndustrializationInfantInfant HealthInfant and Child DevelopmentInterventionInvestigationInvestigatorsLanguage DevelopmentLifeLife StyleLifestyleLinkLiteratureLongitudinal StudiesLongitudinal SurveysMaternal and Child HealthMeasuresMessenger RNAMicroRNAsMolecularMonitorNIEHSNational Institute of Environmental Health SciencesNeural DevelopmentNewborn InfantNewbornsNormal PlacentomaOrgan SystemOutcomePFASParturitionPerinatalPeripartumPhasePhysical activityPhysiopathologyPlacentaPlacenta Embryonic TissuePlacentomePoly-fluoroalkyl substancesPregnancyProcessProductionRandomized, Controlled TrialsRecording of previous eventsRegulationResearchResearch PersonnelResearchersResistanceRiskRoleSamplingSerumTestingTimeTissue GrowthUmbilical CordUmbilical cord structureVisitacquiring language skillsactive followupage 5age 5 yearsattenuateattenuatesbiologicchronic disordercognitive developmentcognitive functioncohortconsumer productdesigndesigningdevelopmentalenvironmental contaminantepigenomicsexercise interventionexposed human populationexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfetalfive year oldfive years of agefollow upfollow-upfollowed upfollowupfunctional genomicshistorieshuman exposureimprovedinfancyinfantilekidslanguage acquisitionlanguage learninglater in lifelater lifelife style interventionlifestyle interventionlong-term studylongitudinal outcome studieslongitudinal research studymRNAmethylomemiRNAmultiomicsmultiple omicsneurodevelopmentnewborn childnewborn childrennoveloffspringontogenypanomicspathophysiologyperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancesperinatal periodperinatal phasephysical activity interventionpolyfluorinated alkyl substancespolyfluoroalkyl substancespostnatalprenatalprenatal environmental exposureprenatal influenceprogramsprotective effectrandomized control trialresistantresponsesocial roleunbornyoungster
Description preview
PROJECT SUMMARY
The perinatal period is well-recognized as a critical developmental window where organ systems are rapidly
growing and tuning their functional programs. This is also a time when environmental exposures can have
profound and long-term impacts on health if they disrupt these processes. Per- and polyfluoroalkyl substances
(PFAS), a…
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