grant
Perinatal Gonadal Hormones Impart Male-Biased Neuroimmune, Mitochondrial, and Behavioral Vulnerabilities.
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AblationAndrogen ReceptorAndrogenic AgentsAndrogenic CompoundsAndrogensAnteriorAquadiolAutopsyBehavioralBioenergeticsBirthBrainBrain Nervous SystemBrain regionCMKRL2CausalityCell Communication and SignalingCell SignalingChemokine Receptor-Like 2CognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDataDevelopmentDifferences between sexesDiffers between sexesDimenformonDiogynDiogynetsDisproportionate number of menDisproportionately impacts malesDisproportionately in menDisturbance in cognitionERalphaERαESR1ESR1 geneElectron TransportEncephalonEndocrine Gland SecretionEndotoxinsEstraceEstradiolEstradiol Receptor alphaEstradiol Receptor αEstradiol-17 betaEstradiol-17betaEstraldineEstrogen Receptor 1Estrogen Receptor alphaEstrogen Receptor αEstrogen ReceptorsEtiologyFemaleFliesG Protein-Coupled Estrogen ReceptorG Protein-Coupled Receptor 30GPERGPER geneGPR30Gender BiasGene ExpressionGenesGonadal HormonesHormonesHortega cellImmuneImmunesImpaired cognitionIncidenceIndividualInfectionInflammatoryInjectionsIntracellular Communication and SignalingKnowledgeLifeLinkLipopolysaccharidesMasculineMasculinityMiceMice MammalsMicrogliaMitochondriaModelingMorphologyMurineMusNR3A1Neural DevelopmentNeurodevelopmental DisorderNeuroimmuneNeurological Development DisorderOvocyclinOvocylinParturitionPathway interactionsPerinatalPeripartumPhagocytosisPlayPredispositionProcessProgynonProteinsReceptor ProteinReceptor SignalingRegulationReportingRoleSex BiasSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSocial BehaviorSusceptibilitySymptomsSynapsesSynapticTestosteroneTherapeutic AndrogenTherapeutic EstradiolTherapeutic HormoneTherapeutic TestosteroneTrans-TestosteroneWorkanxiety-like behaviorbehavior changebehavior outcomebehavioral outcomebiological signal transductionbrain cellcausationcingulate cortexcognitive dysfunctioncognitive losscritical perioddevelopmentaldisease causationdisease riskdisorder riskdisproportionately affects malesdisproportionately affects mendisproportionately concentrated among mendisproportionately distributed among mendisproportionately higher among mendisproportionately impacts mendisproportionately occurs in menearly onsetelectron transferflyfocus on malefocused on mengitter cellmalemale biasmale focusedmale predominancemale specificmale targetedmen disproportionately diagnosedmen disproportionately experiencemen experience disproportionate ratesmesogliamicroglial cellmicrogliocytemitochondrialmitochondrial metabolismmouse modelmurine modelnecropsyneural circuitneural circuitryneurocircuitryneurodevelopmentneurodevelopmental diseasenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwayperinatal brainperinatal periodperinatal phaseperivascular glial cellpostmortempredominantly affecting menprogramspupreceptorresponsesexsex based differencessex-dependent differencessex-related differencessex-specific differencessocialsocial rolesociobehaviorsociobehavioralsynapsesynaptic circuitsynaptic circuitrytargeted to men♀♂
Description preview
This R01 proposal tests the central hypothesis that gonadal hormones present during a critical window of
perinatal brain organization result in distinct sex-specific microglial and mitochondrial phenotypes that increase
male vulnerability to perinatal immune stimuli. There is a strong male bias in the incidence of many early-onset…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click