grant
Perfluorooctanoic acid: a potential environmental modulator of susceptibility to gestational diabetes mellitus
Organization UNIVERSITY OF ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20255-HT5-Hydroxytryptamine5HTAbdominal DeliveryAbnormal Assessment of MetabolismAdult-Onset Diabetes MellitusAgeAgonistAlkaline PhosphataseAllelesAllelomorphsAreaB9 endocrine pancreasBeta CellBindingBioavailabilityBiological AvailabilityBiologyBirth WeightBloodBlood Reticuloendothelial SystemBlood SerumBody CompositionBreathingC sectionC57BL/6 MouseCell CycleCell Division CycleCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCellular biologyCesareanCesarean sectionClinical TreatmentCongenic MiceD-GlucoseDataDeveloping fetusDevelopmentDextroseDiabetes MellitusDietDisparateDoseEPH GestosisEndocrine DisrupterEndocrine Disrupting ChemicalsEndocrine DisruptorsEndocrine PancreasEndocrine disrupting agentEnteramineEnvironmentEnvironmental ExposureEnvironmental PollutantsEthnic OriginEthnicityExposure toFaceFetal DevelopmentFetusGene variantGene x Environment InteractionGenesGeneticGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGestationGestational DiabetesGestational Diabetes MellitusGlucoseGlucose IntoleranceGlucose tolerance testGxE interactionHealthHippophaineHousehold ProductsHousehold SuppliesHumanHydrogen OxideHyperglycemiaHypoglycemiaIPGTTImmunofluorescenceImmunofluorescence ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIndividualInherited PredispositionInherited SusceptibilityInsulin CellInsulin ResistanceInsulin Secreting CellIslands of LangerhansIslets of LangerhansKetosis-Resistant Diabetes MellitusKnowledgeLinkLiquid ChromatographyMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMaternal AgeMaternal and Child HealthMaturity-Onset Diabetes MellitusMeasuresMetabolicMetabolic DiseasesMetabolic DisorderMetabolic StudiesMetabolism StudiesMiceMice MammalsMiscarriageModern ManMolecularMolecular InteractionMorphologyMurineMusNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNutritionalOutcomePancreasPancreaticPancreatic IsletsPancreatic beta CellPancreatic β-CellPars endocrina pancreatisPathway interactionsPhenotypePhysiologic AvailabilityPopulationPre-EclampsiaPredispositionPreeclampsiaPregnancyPregnancy ComplicationsPregnancy ToxemiasPregnancy-Induced DiabetesPregnant WomenPremature BirthPrematurely deliveringPreterm BirthPrevalenceProcessProteinuria-Edema-Hypertension GestosisPublishingPyridoxal 5-PhosphatePyridoxal PhosphatePyridoxinPyridoxolRaceRacesReceptor ProteinRegulationResearchResolutionRespiratory AspirationRespiratory InspirationRiskRisk FactorsRoleSerotoninSerotonin ProductionSerumSlow-Onset Diabetes MellitusSocio-economic statusSocioeconomic StatusSoilSpontaneous abortionStable Diabetes MellitusStructure of beta Cell of isletSubcellular ProcessSusceptibilityT2 DMT2DT2DMTestingThesaurismosisTryptophan 5-monooxygenaseTryptophan HydroxylaseTryptophan MonooxygenaseType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVIT B6Vitamin B 6Vitamin B6WaterWomanWorkadult onset diabetesage at pregnancyagesalkaline phosphomonoesteraseallelic variantblood glucose regulationcell biologyclinical interventionclinical therapycomplications during pregnancycongeniccyclin G1developmentaldiabetesdiagnostic criteriadietarydietsdrinking waterendocrine disrupting compoundenvironment effect on geneenvironmental contaminantexpectant motherexpectant womenexpecting motherexpecting womenexperimentexperimental researchexperimental studyexperimentsfacesfacialgene environment interactiongenetic etiologygenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenomic variantglucose controlglucose homeostasisglucose metabolismglucose regulationglycerophosphatasehigh riskhyperglycemichypoglycemichypoglycemic episodesimprovedindividuals who are pregnantinsightinspirationinsulin resistantinsulin secretioninsulin sensitivity testinsulin toleranceinsulin tolerance testinsulin-induced hypoglycemia testintraperitoneal glucose tolerance testisletketosis resistant diabeteslater in lifelater lifematurity onset diabetesmetabolic abnormality assessmentmetabolism disordernovelnutritiousoffspringpancreas beta cellpancreas β cellpancreatic b-cellpathwaypeople who are pregnantperfluorooctanoateperfluorooctanoic acidpre-eclampticpregnancy diabetespregnancy toxemia/hypertensionpregnancy-related complicationspregnantpregnant femalespregnant motherspregnant peoplepregnant populationspremature childbirthpremature deliverypreterm deliverypreventpreventingpyridoxineracialracial backgroundracial originreceptorresolutionsscreeningscreeningssocial rolesocio-economic positionsocioeconomic positionthose who are pregnanttrial regimentrial treatmenttryptophan 5 hydroxylasetype 2 DMtype II DMtype two diabeteswomen who are pregnantβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY
Gestational diabetes mellitus (GDM) is a form of diabetes that manifests during pregnancy and is
characterized by hyperglycemia and glucose intolerance due to pregnancy-driven insulin resistance and
inadequate pancreatic beta cell adaptation. GDM has a worldwide prevalence of 1.1-31.5 % and is influenced
by race, ethnicity, age,…
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