grant
Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic Children
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Apr 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20260-11 years old0-4 weeks old2 year old2 years of age21+ years oldActinomycesAdultAdult HumanAdult-Onset Diabetes MellitusAgeAge MonthsAmino AcidsArchivesBMIBMI percentileBMI z-scoreBacteriaBacteroidesBile AcidsBiologicalBloodBlood Reticuloendothelial SystemBody mass indexBreast Cancer DetectionBreast FeedingBreast MilkBreast cancer screeningBreast screeningBreastmilkCaliforniaCanadaCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemChemicalsChildChild YouthChildhoodChildren (0-21)DataDevelopmentDiseaseDisorderDrynessEventExcretory functionExposure toFeeding behaviorsFunctional MetagenomicsFundingFutureGI microbiomeGI microbiotaGastrointestinal microbiotaGeneralized GrowthGestationGoalsGrowthHeart VascularHispanicHispanic PopulationsHispanic groupHispanic individualHispanic peopleHispanicsHumanHuman MilkHuman Mother's MilkIndividuals from minorityIndividuals of minorityInfantIngestive BehaviorInterventionInvestigatorsKetosis-Resistant Diabetes MellitusLactationLactobacillusLifeLinkLipidsLiteratureLongitudinal StudiesLongitudinal SurveysMammary Gland MilkMaternal HealthMaturity-Onset Diabetes MellitusMeasuresMetabolic PathwayMetabolic syndromeMetagenomicsMilkMinority GroupsMinority PeopleMinority PopulationMinority individualModalityModern ManMother's MilkMothersNIDDMNational Institutes of HealthNewborn InfantNewbornsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityObesity EpidemicPFASPhysical activityPoly-fluoroalkyl substancesPredispositionPregnancyPreventative measurePreventive measureProbioticsProductionQuetelet indexReportingResearchResearch PersonnelResearchersRiskSamplingShort-Chain Fatty AcidsSlow-Onset Diabetes MellitusSourceSpottingsStable Diabetes MellitusSubgroupSusceptibilityT2 DMT2DT2DMTestingTissue GrowthTransmissionType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnhealthy DietUnited States National Institutes of HealthVolatile Fatty AcidsWeightYouthYouth 10-21adipogenesisadiposityadult onset diabetesadulthoodage 2age 2 yearsaged 2 yearsaged two yearsagesaminoacidbacteria in the gutbile acid metabolismbile metabolismbiologiccardiovascular disorderchild adipositychild obesitychildhood adipositychildhood obesitycirculatory systemco-morbidco-morbiditycohortcomorbiditycorpulencecritical perioddevelopmentaldigestive tract microbiomedrinking waterearly life exposureearly-onset obesityenergy balanceenteric microbial communityenteric microbiomeenteric microbiotaenvironmental chemicalexcretionexperimentexperimental researchexperimental studyexperimentsexposed human populationexposed in uterofatty liver diseasefecal metabolomefecal samplefeeding-related behaviorsfetal exposuregastrointestinal microbial floragastrointestinal microbiomegut bacteriagut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiome of infantgut microbiotagut microbioticgut microfloragut-associated microbiomehigh riskhuman exposureimprovedin utero exposureinfancyinfant gut microbiomeinfantileinsightintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraintra-uterine environmental exposureintrauterine environmental exposureketosis resistant diabeteskidslack of physical activitylactatinglactationallater in lifelater lifelipid biosynthesislipogenesislong-term studylongitudinal outcome studieslongitudinal research studymammary cancer detectionmammary screeningmaternal milkmaturity onset diabetesmetabolism measurementmetabolomicsmetabonomicsmicrobialmultidisciplinarymultiomicsmultiple omicsneonate gut microbiomenewborn childnewborn childrennewborn gut microbiomenovelnutrient intake activityobese childrenobesigenicobesity during childhoodobesity in childrenobesity interventionobesity preventionobesity riskobesity therapyobesity treatmentobesogenicontogenypanomicspediatricpediatric obesityperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancesphysical inactivitypolyfluorinated alkyl substancespolyfluoroalkyl substancespoor dietpostnatalprenatalprenatal exposureprenatally exposedpreventprevent obesitypreventingpublic health prioritiesrapid growthrapid infant weight gainrisk for obesityrisk of obesityscreeningscreeningsstool samplestool specimentransmission processtwo year oldtwo years of agetype 2 DMtype II DMtype two diabetesunbornunder served communityunderserved communityweightsyoungsteryouth age
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ABSTRACT
Childhood obesity is a high priority public health issue as it increases the risk of co-morbid diseases, including
cardiovascular disease, fatty liver disease, and type 2 diabetes. An improved understanding of the factors that
trigger the development of early life obesity is urgently needed. This is especially important among Hispanics, a…
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