grant
Peptide Processing by Copper Enzymes
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 1 May 2020Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026Anti-Bacterial AgentsCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCell membraneChemistryClinicComplexCopperCoupledCryo-electron MicroscopyCryoelectron MicroscopyCu elementCytoplasmic MembraneDataDopamine-beta-monooxygenaseEPR spectroscopyESR SpectroscopyElectron CryomicroscopyElectron Paramagnetic ResonanceElectron Spin ResonanceElectron Spin Resonance SpectroscopyElectronicsEndocrine Gland SecretionEnzyme GeneEnzymesFundingG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGLP-1GPCRGlp-1HomocysteineHormonesHydroxylationLeadMediatingMetalsMolecular ConfigurationMolecular ConformationMolecular StereochemistryNuclearOzempicParamagnetic ResonancePathway interactionsPb elementPeptide SynthesisPeptidesPlasma MembraneProductionReactionRibosomesRoentgen RaysRybelsusSiteSourceSuggestionViral CancerWegovyX-RadiationX-Ray RadiationX-rayXrayalpha-amidating enzyme AE-IIamidationanaloganti-bacterialanti-cancer therapeuticconformationconformationalconformational conversionconformational stateconformational transitionconformationallyconformationscrosslinkcryo-EMcryoEMcryogenic electron microscopydesigndesigningdopamine beta hydroxylasedopamine β-hydroxylaseelectron paramagnetic resonance spectroscopyelectronicelectronic deviceglucagon-like peptide 1heavy metal Pbheavy metal leadpathwaypeptidyl alpha-amidating monooxygenasepeptidyl-glycine alpha-amidating monooxygenasepeptidylglycine 2-hydroxylasepeptidylglycine alpha-amidating monooxygenasepeptidylglycine alpha-hydroxylating monooxygenasepeptidylglycine hydroxylasepeptidylglycine monooxygenaseplasmalemmaprogramssemaglutide
Description preview
ABSTRACT
Peptide processing is a post-translational function that converts pro-peptides into their mature forms. Amidated
peptides interact with GPCRs at the cell membrane leading to production of essential hormones, while NRPS
or RiPPs are a major source of lead compounds for antibacterial, antiviral and anticancer therapeutics. Our
R35 program…
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