grant
Pediatric Solid Tumor Microenvironment Atlas
Organization CHILDREN'S HOSPITAL OF LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAddressAdolescent and Young AdultAdultAdult HumanAdversarial model trainingAdversarial trainingAfter CareAfter-TreatmentAftercareAntibodiesAtlasesAutomobile DrivingBiologyBone-Derived Transforming Growth FactorCaliforniaCancer BiologyCancer TreatmentCancersCell BodyCell LineageCellsCephalicChildChild YouthChildhoodChildhood CancersChildhood NeoplasmChildhood Solid NeoplasmChildhood Solid TumorChildhood TumorChildren (0-21)Children's HospitalClassificationClinicalCollaborationsCommunitiesComplexCoupledCranialCytotoxic ChemotherapyCytotoxic TherapyDNADNA mutationDataData AnalyticsData ScienceDeoxyribonucleic AcidDevelopmentDiagnosticDiseaseDisease-Free SurvivalDisorderEnsureEnvironmentEvent-Free SurvivalFibroblastsGenerationsGenesGenetic ChangeGenetic defectGenetic mutationGoalsImmuneImmune mediated therapyImmunesImmunologically Directed TherapyImmunotherapyInstitutionIntratumoral heterogeneityInvestigationKnowledgeLeadLos AngelesMacrophageMalignant CellMalignant Childhood NeoplasmMalignant Childhood TumorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerMediatingMesenchymalMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMilk Growth FactorModernizationMorbidityMorbidity - disease rateMotivationMutationMφNeighborhoodsNeoplasm MetastasisNephroblastomaNeuroblastomaNon-Polyadenylated RNAOutcomePathway interactionsPatientsPb elementPediatric HospitalsPediatric NeoplasmPediatric Solid TumorPediatric TumorPhenotypePlatelet Transforming Growth FactorPopulationProbabilityProcessPrognosisProteinsProteomicsRNARNA Gene ProductsRecoveryRecurrenceRecurrentRelapseRenal Wilms' TumorResearchResearch ResourcesResearch SpecimenResistanceResourcesRhabdomyosarcomaRibonucleic AcidRoleSamplingSecondary NeoplasmSecondary TumorSolid NeoplasmSolid TumorSpecimenSystematicsT-CellsT-LymphocyteTGF BTGF-betaTGF-βTGFbetaTGFβTechnologyTherapeuticTissue SampleTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTumor BiologyTumor CellTumor SubtypeTumor-associated macrophagesWilm's TumorWilms TumorWilms' Tumor of the Kidneyadulthoodadversarial approachadversarial learningadversarial strategyanalysis pipelineanti-cancer therapycancer cellcancer in a childcancer in childrencancer metastasiscancer microenvironmentcancer progressioncancer therapycancer-directed therapycausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell typechemotherapychild with cancerchildhood malignancyclinical research siteclinical riskclinical sitecomputational pipelinesdata acquisitiondata acquisitionsdevelopmentaldrivingembryo cellepithelial to mesenchymal transitionethnic diversityethnically diversegenome mutationheavy metal Pbheavy metal leadheterogeneity in tumorshigh riskimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedimproved outcomeinnovateinnovationinnovativeinsightintra-tumoral heterogeneityintratumor heterogeneitykidsmalignancymultidisciplinaryneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnovelpathwaypatient populationpediatricpediatric cancerpediatric malignancypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpost treatmentprogramsresistance to therapyresistantresistant to therapyresponders and non-respondersresponders from non-respondersresponders or non-respondersresponders versus non-respondersresponders vs non-respondersresponders/nonrespondersresponseresponse to therapyresponse to treatmentrisk stratificationsearchable data basesearchable databasesocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial multiomicsspatial omicsspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicsstemstratify risktargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapeutic responsetherapeutically effectivetherapy resistanttherapy responsethymus derived lymphocytetooltreatment resistancetreatment responsetreatment responsivenesstumortumor cell metastasistumor heterogeneitytumor microenvironmenttumor progressiontumors in childrenuser-friendlyyoungster
Description preview
OVERALL SUMMARY/ABSTRACT
The majority of solid tumors in children have a unique origin compared to those in adults, stemming from their
rise from embryonic cells. Despite this distinction, there is still limited understanding of the differences in the
microenvironments of these pediatric tumors compared to adult cancers, and how these differences…
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