grant
Pediatric POTS: does a periaqueductal gray-vagus nerve interface malfunction explain the natural history with its numerous co-morbidities ?
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 15 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202612 year old12 years of age12-20 years oldAbsence of pain sensationAbsence of sensibility to painAccountingAcuteAdolescenceAdolescentAdolescent YouthAdolescent and Young AdultAdult femalesAdult womenAreaBlood PressureBradycardiaBrainBrain Nervous SystemBrain VascularBrain imagingBrain regionCardiac ChronotropismCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCausalityCentral LobeCessation of lifeChildhoodChronicClassificationClinicalConnective TissueCoping SkillsCranial Nerve XCuriositiesDeathDecreased Muscle ToneDiffuse Myofascial Pain SyndromeDisablingDiseaseDisorderDizzinessDropsEmotionalEncephalonEquipment and supply inventoriesEstrogen ReceptorsEtiologyEvolutionExhibitsFailureFeels no painFemale AdolescentsFemales in adulthoodFibromyalgiaFibromyositis-Fibromyalgia SyndromeFibrositisFlareFrequenciesFunctional Gastrointestinal DisordersFunctional MRIFunctional Magnetic Resonance ImagingHeart RateHeart VascularHospital AdmissionHospitalizationHourHypomyotoniaHypotensionHypotoniaImageImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInfectionInsulaInsula of ReilInventoryIrritable Bowel SyndromeIrritable ColonIsland of ReilLifeLinkLow Blood PressureMPD syndromeMarrow Mast CellMeasuresMediatingMenarcheMesencephalic Central GrayMesencephalonMid-brainMidbrainMidbrain Central GrayMidbrain structureMigraineMigraine HeadacheModelingMotorMucous ColitisMuscle HypotonyMuscle Tone PoorMuscle hypotoniaMuscular HypotoniaMuscular RheumatismNatural HistoryNauseaNo sensitivity to painOrganOutcomePainPainfulPatientsPeriaqueductal GrayPeripheralPharmacologyPneumogastric NervePopulationPostural Orthostatic Tachycardia SyndromePostural Tachycardia SyndromePrefrontal CortexPreparednessProspective StudiesReadinessRecoveryRegulationReportingRestSample SizeSchoolsScienceSeveritiesSocial DevelopmentStimulusStress and CopingSymptomsSystemSystematicsTenth Cranial NerveTestingTilt-Table TestTimeTissue BasophilsTraumaVagus NerveVagus nerve structureVascular Hypotensive DisorderVasomotorWomen in adulthoodWorkadolescence (12-20)adolescent girlage 12age 12 yearsanalgesiaannulus of the aqueductbrain fogbrain visualizationcausationcerebral vascularcerebro-vascularcerebrovascularchronic pain conditionchronic pain disorderchronic painful conditioncirculatory systemco-morbidco-morbiditycohortcomorbiditycopingcoping strategycoping with stressdisease causationestrogen receptor proteinestrophileestrophilinexhaustfMRIfemale subjectsfibromyalgia syndromeflexibilityflexiblefunctional disabilitygirlsheart rate variabilityimagingimprovedjuvenilejuvenile humanmast cellmastocytemeetingmeetingsmidbrain central gray substancemyofascial pain dysfunction syndromenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpain processingpain signalpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespediatricperiaqueductal gray matterpost-orthostatic tachycardiapostural orthostatic tachycardiaprospectiveprospective research studyprospective surveypsychologic traumapsychological shockpsychological traumaresponseresponse to therapyresponse to treatmentspastic colonstress-related copingtheoriestherapeutic responsetherapy responsetreatment responsetreatment responsivenesstwelve year oldtwelve years of agewomen subjects
Description preview
PROJECT SUMMARY / ABSTRACT
Postural tachycardia syndrome (POTS) is a common, disabling disorder among adolescents, interfering
with their schoolwork, physical and social development. It occurs most often in adolescent females post-
menarche. The combination of orthostatic symptoms such as dizziness, nausea, weakness, or brain fog
with a 40 bpm…
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