grant
Peaks to genes: Fine mapping of QTLs and functional analysis
Organization UNIVERSITY OF NOTRE DAMELocation NOTRE DAME, UNITED STATESPosted 1 Aug 2017Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AllelesAllelomorphsBioinformaticsCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCandidate Disease GeneCandidate GeneCas nuclease technologyCell Communication and SignalingCell SignalingChromosome MappingClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsCommunitiesDNA mutationDataData BasesData SetDatabasesDrug resistanceExclusionExperimental GeneticsFundingGene AlterationGene LocalizationGene MappingGene Mapping GeneticsGene MutationGenesGenetic ChangeGenetic CrossesGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenomicsGenotypeGoalsHaplotypesIndividualInsertional MutagenesisIntracellular Communication and SignalingKnock-outKnockoutLibrariesLifeLinkLinkage MappingLocationMalariaMapsMethodsMolecularMutagenesisMutagenesis Molecular BiologyMutationP falciparumP falciparum genomeP. falciparumP. falciparum genomeP.falciparumPaludismParasitesParentsPhasePhenotypePlasmodiumPlasmodium InfectionsPlasmodium falciparumPlasmodium falciparum genomePlayPopulationProteinsQTLQuantitative Trait LociRecombinantsResearch ResourcesResourcesRodentRodentiaRodents MammalsRoleSignal TransductionSignal Transduction SystemsSignalingTotal Human and Non-Human Gene MappingValidationVariantVariationWorkbio-informatics toolbioinformatics toolbiological signal transductioncandidate identificationcandidate validationcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcombinatorialconditional knock-outconditional knockoutdata basedata toolsdeep sequencingdrug resistantentire genomeexperimentexperimental researchexperimental studyexperimentsfull genomegene defectgene interactiongene manipulationgene networkgenetic manipulationgenetic mappinggenetically manipulategenetically perturbgenome mutationgenomic datagenomic datasetinterestmutant allelenano porenanoporenanopore based sequencingnanopore long read seqnanopore long-read sequencingnanopore seqnanopore sequencingnanopore-based long-read sequencingparentprogramsrapid methodrapid techniqueresistance generesistance locusresistance to Drugresistant generesistant to Drugsocial rolestructural mutationstructural variantstructural variationtelomeretraitvalidationswhole genome
Description preview
PROJECT SUMMARY
Linkage mapping using genetic crosses results in identification of quantitative trait locus (QTL) regions
that may contain tens to hundreds of genes. Identification of the causative genes therefore requires
careful prioritization of candidate loci, followed by gene manipulation studies to validate the best
candidates, and…
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