grant
Patterns of biological, cognitive, and physical aging in cancer survivors and controls and the role of sleep health: Relevance for Alzheimer's Disease and Related Dementias
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 15 Jun 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDActive Follow-upAddressAffectAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAreaAssayAutoregulationBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBioassayBiologicalBiological AgingBiological AssayBiological Specimen BanksBiological Substance BanksBiological TestingBloodBlood Reticuloendothelial SystemBlood leukocyteBreast CancerBreast Cancer PatientBreast Cancer survivorBreast Cancer therapyBreast Tumor PatientCancer CenterCancer ControlCancer Control ScienceCancer SurvivorCancer TreatmentCancersCell AgingCell SenescenceCellular AgingCellular SenescenceChronologyCognitiveCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalConditioning TherapyConsentControl GroupsDNA DamageDNA InjuryDataDemographic FactorsDiseaseDisorderDisturbance in cognitionEducational AchievementEducational StatusElderlyEnrollmentEpigenetic ageFrequenciesFutureGeriatricsGeroscienceGoalsGrantGrip strengthHand StrengthHealthHeterogeneityHomeostasisImpaired cognitionIndianaInflammationInterventionKnowledgeLeadLengthLeukocytesLeukocytes Reticuloendothelial SystemLong-Term EffectsLong-term cohortLongitudinal cohortMalignant Breast NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMarrow leukocyteMeasurementModelingNational Institutes of HealthNeurocognitiveNeurosciencesNewly DiagnosedObesityOncologyOncology CancerParentsPathway interactionsPatient Self-ReportPatternPb elementPersonsPhysical FunctionPhysical assessmentPhysiological HomeostasisPopulationPrimary Senile Degenerative DementiaPsychosocial FactorRNA SeqRNA sequencingRNAseqRacial GroupRegulationReplicative SenescenceResearchRiskRoleSYS-TXSelf-ReportSiteSleepSurvivorsSyndromeSystemSystemic TherapyTestingThinkingTimeUnited States National Institutes of HealthUniversitiesVisitWaste ProductsWhite Blood CellsWhite CellWomanWorkaccelerated agingaccelerated biological ageaccelerated biological agingactigraphactigraphyactive followupadiposityadvanced ageage accelerationage associatedage correlatedage dependentage linkedage relatedage related pathwaysage specificagedaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging associatedaging associated mechanismaging biological markeraging biomarkeraging markeraging mechanismaging pathwayaging populationaging processaging relatedaging related mechanismaging related pathwaysalzheimer riskanti-cancer therapybehavior interventionbehavioral interventionbiobankbiologicbiological agebiological mechanism of agebiological pathways of agebiological process of agebiological specimen repositorybiorepositorybiosample repositorybiospecimen bankbiospecimen repositorycancer therapycancer-directed therapyclinical translationclinically translatablecognitive dysfunctioncognitive functioncognitive losscohortcompare to controlcomparison controlcorpulencedecline in functiondecline in functional statusdrivers of agingeducational levelenrollfollow upfollow-upfollowed upfollowupfunctional declinefunctional status declinegeriatricgeriatric medicinegerodrivergeroscientificheavy metal Pbheavy metal leadimprovedimprovement on sleepindividuals with breast cancermalignancymalignant breast tumormechanism regulating agingmechanisms involved in agingmultimorbiditymultiple chronic conditionsneoplasm/cancerneurocognitive testnovelolder womenparentparent grantpathwaypathway involved in agingpatients with breast cancerperson with breast cancerpoor sleeppopulation agingprimary degenerative dementiaprimary outcomeprospective testpsychosocial variablesracial populationracial subgrouprecruitrepairrepairedreplicative agingresilienceresilientsenile dementia of the Alzheimer typesenior citizensleep healthsleep hygienesleep improvementsleep wellnesssocial rolespecimen bankspecimen repositorytelomeretheoriesthoughtstraining achievementtraining leveltraining statustranscriptome sequencingtranscriptomic sequencingwhite blood cellwhite blood corpuscle
Description preview
Abstract
We use a geroscience framework to advance Alzheimer’s disease-related dementias (ADRD) research by
establishing how biological aging affects cognitive and physical decline and defining the role of sleep in these
relationships. We use the interface of aging and breast cancer in older women for this purpose because of their
unique…
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