grant
Patient-Oriented Research Mentoring for the Investigation of Acute and Chronic Sickle Cell Disease Pain
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years oldAbscissionAcuteAcute PainAcutely painfulAddressAdolescentAdolescent YouthAdultAdult HumanAdvisory CommitteesAffectAnalgesia TestsAreaAsthmaAwardAwarenessB-globinBiologicalBiological MarkersBiologyBlack PopulationsBlack groupBlack individualBlack peopleBlacksBlood PlasmaBlood erythrocyteBronchial AsthmaCardiovascular DiseasesChronicChronic DiseaseChronic IllnessClinical InvestigatorComplicationDNA mutationDataDevelopmentEnvironmentErythrocytesErythrocyticExcisionExtirpationFaceFacultyFrequenciesFutureFuture GenerationsGene TranscriptionGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsHb SS diseaseHbSS diseaseHealthHealth CareHealth Care UtilizationHemoglobin SHemoglobin S DiseaseHemoglobin sickle cell diseaseHemoglobin sickle cell disorderHemoglobinopathiesHemolysisHereditaryHypophysisHypophysis CerebriHypothalamic structureHypothalamusImmuneImmune responseImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImpairmentImpoverishedIndividualInequityInflammationInflammatoryInflammatory ResponseInheritedInvestigationIschemia-Reperfusion InjuryK24 AwardKnowledgeMarrow erythrocyteMediatingMentorsMentorshipMid-Career Clinical Scientist Award (K24)MorbidityMorbidity - disease rateMutationNociception TestsOutcomePainPain AssessmentPain ControlPain MeasurementPain ResearchPain TherapyPain managementPain measurePainfulPathogenesisPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPersonsPhenotypePhysiciansPituitaryPituitary GlandPituitary Nervous SystemPlasmaPlasma SerumPopulationPovertyProcessPsychoneuroimmunologyRNA ExpressionRed Blood CellsRed CellRegulationRemovalReperfusion DamageReperfusion InjuryResearchReticuloendothelial System, Serum, PlasmaScientistSeveritiesSickle CellSickle Cell AnemiaSickle HemoglobinSourceStressSurgical RemovalSympathetic Nervous SystemTask ForcesTestingTimeTrainingTranscriptionUnderserved PopulationVariantVariationWisconsinWorkacute careadulthoodadvisory teambarrier to carebarrier to health carebarrier to treatmentbeta Globinbio-markersbiologicbiologic markerbiomarkerblood corpusclescardiovascular disordercare utilizationcareerchronic disorderchronic paincompare to controlcomparison controlcytokinedaily paindebilitating paindevelopmentaldiscrimination based on racediscrimination due to racedisparity in caredisparity in health careeffective therapyeffective treatmenterythrolysisfacesfacialfood insecuritygenome mutationhealth care disparityhealth care inequalityhealth care inequityhealth care service usehealth care service utilizationhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhost responsehousing instabilityhypothalamicimmune system responseimmunoresponseimprovedindexinginnovateinnovationinnovativeinstably housedinter-individual variabilityinter-individual variationinterestjuvenilejuvenile humanlack of stable housingmedical collegemedical schoolsnext generationobstacle to careobstacle to health carepain assaypain interventionpain outcomepain treatmentpain-related outcomepatient centeredpatient orientedpatient oriented researchpatient oriented studyprogramspsychologicpsychologicalpsychoneuroimmunologicalrace discriminationrace-based discriminationrace-related discriminationracial discriminationrecruitresectionschool of medicinesickle RBCsickle cell diseasesickle cell disordersickle diseasesickle erythrocytesickle red blood cellsicklemiaskillssocial health determinantsstressortheoriesunder served groupunder served individualunder served peopleunder served populationunderserved groupunderserved individualunderserved peopleunstable housingunstably housedβ-globin
Description preview
The overall goal of this K24 application, “Patient-Oriented Research Mentoring for the Investigation of Acute and Chronic Sickle Cell Disease Pain” is for a mid-career physician-scientist, Dr. Amanda Brandow, to enhance her mentoring skills and develop the next generation of clinical investigators who can advance acute and chronic pain research in…
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