grant
Pathways of peroxidation: defining the autoxidation of polyunsaturated fatty acids and the cellular consequences
Organization LOUISIANA STATE UNIV A&M COL BATON ROUGELocation BATON ROUGE, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AffinityAffinity ChromatographyAmino AcidsAntioxidantsArachidonic Acid CyclooxygenaseAutoregulationBackBacteriaBindingBiologic ModelsBiological FunctionBiological ModelsBiological ProcessCOX-1COX-1 proteinCancersCardiovascular DiseasesCell BodyCell Communication and SignalingCell SignalingCell modelCellsCellular modelCharacteristicsChemistryChronicChronic DiseaseChronic IllnessClinical TrialsComplexCyclo-OxygenaseCyclo-Oxygenase-1CyclooxygenaseCyclooxygenase 3Diabetes MellitusDiseaseDisorderDoctor of PhilosophyDorsumEnzyme GeneEnzymesFailureFatty Acid Cyclo-OxygenaseFatty Acid CyclooxygenaseFutureGenerationsHomeostasisHumanHuman FigureHuman bodyHydroperoxide CyclaseInflammationInjuryIntracellular Communication and SignalingInvadedLinoleate-Oxygen OxidoreductaseLipidsLipoxidaseLipoxygenaseMalignant NeoplasmsMalignant TumorMammalian CellMapsMediatingMetabolicMitochondriaMitochondrial ProteinsModel SystemModern ManMolecularMolecular InteractionNerve DegenerationNeuron DegenerationPGH SynthasePGH Synthase 1PGH2 SynthetasePathologyPathway interactionsPh.D.PhDPhysiological HomeostasisPolyunsaturated Fatty AcidsPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPredispositionProcessProstaglandin Cyclo-OxygenaseProstaglandin CyclooxygenaseProstaglandin Endoperoxide SynthetaseProstaglandin G-H SynthaseProstaglandin G/H Synthase 1Prostaglandin H SynthaseProstaglandin H2 SynthaseProstaglandin H2 Synthase 1Prostaglandin H2 SynthetaseProstaglandin SynthaseProstaglandin SynthetaseProstaglandin-Endoperoxide SynthaseProstaglandin-Endoperoxide Synthase 1Protein ModificationProteinsProteomicsReactionResearchRoleS aureusS. aureusSignal TransductionSignal Transduction SystemsSignalingSourceStaph aureusStaphylococcus aureusStructureSusceptibilitySystemToxic effectToxicitiesValidationadductaffinity purificationaminoacidbiological signal transductioncardiovascular disordercarotene oxidasechronic disordercyclo-oxygenase Icyclooxygenase 1designdesigningdiabeteshuman diseaseinjuriesmalignancymitochondrialneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationoxidationpathogenpathwayperoxidationpreventpreventingprogramsprostaglandin H synthase-1protein functionsmall moleculesocial roletissue repairtoolvalidations
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Project Summary/Abstract
Inflammation is a tightly regulated and necessary biological process that protects humans from invading
pathogens and repairs tissue following injury. Failure to resolve inflammation is associated with the pathology
of many chronic diseases including cancers, cardiovascular diseases, diabetes, and neurodegeneration.…
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