grant
Pathways of Injury and Repair in Barrett's Carcinogenesis
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 20 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-10CAMCF-IAddressAdenocarcinoma of the EsophagusAdhesion MoleculeAffectBarrett EsophagusBarrett SyndromeBarrett UlcerBarrett's carcinogenesisBasal Transcription FactorBasal transcription factor genesBasic ResearchBasic ScienceBibliometric AnalysisBibliometricsBioinformaticsBiological MarkersBiologyBody TissuesC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1CXCL8Cancer InductionCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell CommunicationCell Communication and SignalingCell DifferentiationCell Differentiation processCell InteractionCell LocomotionCell MigrationCell MovementCell SignalingCell-to-Cell InteractionCellsCellular ExpansionCellular GrowthCellular MigrationCellular MotilityClinicalCollaborationsColumnar Epithelial-Lined Lower EsophagusColumnar-Lined EsophagusComplexDetectionDevelopmentDevicesDiseaseDisorderDuctDuct (organ) structureDysplasiaEPHB2EPHB2 geneEPHT3EPTH3Epithelial Cell JunctionEpitheliumEsophageal AdenocarcinomaEsophageal injuryEsophagusGCP1General Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGlandGoalsGrantHNF4HNF4-AlphaHNF4AHNF4A geneHek5Hepatocyte Nuclear Factor 4-AlphaHepatocyte Nuclear Factor, 4HereditaryHyperactivityIL-8IL8IL8 geneIndividualInflammatoryInflammatory InfiltrateInheritedInherited PredispositionInherited SusceptibilityInjuryInjury to EsophagusInstitutionInterdisciplinary ResearchInterdisciplinary StudyIntracellular Communication and SignalingInvestigatorsJN KinaseJNKJNK Mitogen-Activated Protein KinasesJNK1JNK1 KinaseJNK1 proteinJNK1A2JNK21B1/2K60LaboratoriesLaboratory ResearchLaboratory ScientistsLeadLegal patentMAP Kinase 8MAP Kinase 8 GeneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneManuscriptsMediatingMediatorMetaplasiaMetaplastic ChangeMitogen-Activated Protein Kinase 8MolecularMolecular TargetMorbidityMorbidity - disease rateMultidisciplinary CollaborationMultidisciplinary ResearchMutatePRKM8PatentsPathway interactionsPatternPb elementPhenotypePopulationPredispositionPredisposition genePreventionPrognosisPublic HealthPublishingR-Series Research ProjectsR01 MechanismR01 ProgramRefluxResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearchersResourcesRoleSAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKSCYB8SamplingServicesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSpecialized Program of Research ExcellenceSquamous EpitheliumStatistical BibliographyStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaSubmucosaSusceptibilitySusceptibility GeneSystemTCF14TGF-Beta 1TGF-Beta1TGFBTGFB1TGFB1 geneTSG-1TYRO5TherapeuticTissuesTranscription Factor 14, Hepatic Nuclear FactorTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor Beta 1TranslatingTranslational ResearchTranslational ScienceUniversitiesWound Repairb-ENAPbio-markersbiobankbiologic markerbiological signal transductionbiomarkerbiorepositoryc mycc-jun N-Terminal Kinasec-myc Genescancer preventioncarcinogenesiscarcinogenicitycell adhesion proteincell growthcell motilitycellular differentiationclinical applicabilityclinical applicationcmycdetection methoddetection proceduredetection techniquedevelopmentaldyscrasiaesophageal carcinogenesisesophageal intestinal metaplasiafusion genegenetic approachgenetic etiologygenetic mechanism of diseasegenetic strategygenetic vulnerabilitygenetically predisposedhealingheavy metal Pbheavy metal leadimprovedinjuriesinjury and repairinjury responseinstructorjun-NH2-Terminal Kinasemolecular biomarkermolecular markermortalitymouse modelmurine modelnotchnotch proteinnotch receptorsnovelpathwayprecursor cellpredisposing genepreventpreventingprofessorprogramsrepairrepairedresponse to injuryrisk stratificationscreeningscreeningssocial rolespatial and temporalspatial temporalspatiotemporalstratify riskstress-activated protein kinase 1support networksusceptibility allelesusceptibility locussusceptibility variantsynergismtranscription factortranscriptomicstransforming growth factor beta1translation researchtranslational investigationv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homologwound healingwound recoverywound resolutionwound response
Description preview
PROGRAM SUMMARY
The central hypothesis of this program project is that “Altered squamous epithelial integrity (Prj 1) and
inflammatory injury (Prj 2) activate signaling pathways including EPHB2 (Prj 3) that affect precursor cells
at the squamocolumnar junction (SCj) transition, esophageal submucosal gland (ESMG), and basal
squamous niches,…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click