grant
Pathophysiology of Severe Yellow Fever
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 10 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AffectAfricaAlimentary CanalAmino AcidsAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAntigensAssayAttenuatedBioassayBiological AssayBleedingBlood VesselsBlood flowBrazilBreakbone Fever VirusCell BodyCellsCessation of lifeChimeric VirusChromosome MappingCirculationCollaborationsComplicationCricetinaeDENVDNA Molecular BiologyDNA mutationDataDeathDengue VirusDengue fever virusDevelopmentDigestive TractDiseaseDisorderDysfunctionEgypt 101 virusEndotheliumExtravasationFeverFlavivirusFunctional disorderGI TractGastrointestinal TractGastrointestinal tract structureGene LocalizationGene MappingGene Mapping GeneticsGenesGenetic ChangeGenetic DeterminismGenetic defectGenetic mutationGolden HamstersGolden Syrian HamstersGroup B ArbovirusHamstersHamsters MammalsHemorrhageHepatic CellsHepatic Parenchymal CellHepatocyteHumanIFNImmunocompetentImmunologic FactorsImmunological FactorsImpairmentIn VitroInfectionInterferon Type IInterferonsInterventionIntoxicationIschemiaLeakageLinkage MappingLiverLiver CellsMeasuresMediatingMesocricetus auratusMethodsModelingModern ManMolecularMolecular BiologyMorbidityMosquito-borne diseaseMosquito-borne infectious diseaseMutationOrganOrthoflavivirusPathogenesisPathologistPatientsPhysiciansPhysiopathologyPlayProteinsPyrexiaRecombinant VaccinesRecombinantsResearchResearch SpecimenRoleSeptic ShockSouth AmericaSpecimenSpillageSpinal ColumnSpineSupportive TherapySupportive careSyndromeSyrian HamstersSystemTotal Human and Non-Human Gene MappingToxinTransgenic OrganismsVertebral columnViralViral ChimeraViral Gene ProductsViral Gene ProteinsViral GeneticsViral PathogenesisViral ProteinsViremiaVirulentVirusVirus IntegrationVirus ReplicationWNVWest Nile virusWorkYellow FeverYellow Fever VaccineYellow Fever Virus InfectionYellow fever virusZIKVZika Virusalimentary tractaminoacidanti-viral immunityantiviral immunityattenuateattenuatesattenuationbackbonebacteria in the gutblood lossdevelopmentaldigestive canalfebrilefebrisflexibilityflexiblegastrointestinalgenetic determinantgenetic mappinggenome mutationgut bacteriahemorrhagic fever virushepatic body systemhepatic organ systemhuman pathogenimmune competentimmunogenimmunologic substanceimmunological substanceimprovedinsightliver functionmodel of animalmortalitypathophysiologypreventpreventingrecombinant virusresponsereverse geneticssocial roletooltransgenicvaccine against yellow fevervaccine safetyvascularviraemiaviral genome integrationviral integrationviral multiplicationviral replicationviral sepsisvirus geneticsvirus genome integrationvirus multiplicationvirus pathogenesisvirus proteinvirusemiayellow fever virus vaccinezikav
Description preview
PROJECT SUMMARY/ABSTRACT
Yellow fever (YF) is a serious mosquito-borne disease (~80,000 deaths annually) endemic to Africa and South
America that is poised for emergence/re-emergence on a global scale. YF is caused by the yellow fever virus
(YFV), which replicates primarily in the liver where it causes significant damage and organ dysfunction.…
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