grant
Pathophysiological Study of Alzheimer's Disease and Related Dementia
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAD dementiaAD modelAD related dementiaADRDARNTLARNTL geneAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAminalonAminaloneAmmon HornAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAβBACEBACE1BMAL1Behavior assessmentBehavioralBrainBrain Nervous SystemCircadian DysregulationCircadian RhythmsCognitiveCornu AmmonisDNA mutationDepositDepositionEncephalonExerciseExhibitsFast-Wave SleepFutureGABAGSK-3betaGSK-3βGene ExpressionGenesGenetic ChangeGenetic defectGenetic mutationGenetic predisposing factorGoalsHippocampusHumanHypothalamic structureHypothalamusInterventionLearningLinkMemoryMiceMice MammalsModern ManMolecularMurineMusMutationNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-pharmacologic TherapyNonpharmacologic InterventionNonpharmacologic TherapyNonpharmacologic approachNonpharmacologic treatmentNyctohemeral RhythmParadoxical SleepPatientsPhysical activityPrimary Senile Degenerative DementiaREM SleepResolutionRhombencephalic SleepRunningSleep ArchitectureSleep Wake CycleSleep disturbancesStructureTherapeuticTimeTransgenic MiceTwenty-Four Hour RhythmVascular DiseasesVascular DisorderWorka beta peptideaberrant sleepabetaabnormally aggregated tau proteinalzheimer modelamyloid betaamyloid-b proteinaryl hydrocarbon receptor nuclear translocator-likeaxon damageaxon injuryaxonal damageaxonal injurybehavioral assessmentbeta amyloid fibrilbeta-secretase 1beta-site APP cleaving enzyme 1beta-site amyloid precursor protein cleaving enzyme 1blood vessel disorderbrain healthcircadiancircadian abnormalitycircadian behavioral rhythmscircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercircadian processcircadian rhythmicitycognitive functioncognitive performancecommon symptomdaily biorhythmdebilitating symptomdisrupted sleepdisturbed sleepdreaming sleepeffective therapyeffective treatmentfilamentous tau inclusionfunctional outcomesgamma-Aminobutyric Acidgene manipulationgenetic manipulationgenetic risk factorgenetically manipulategenetically perturbgenome mutationglycogen synthase kinase 3 betaglycogen synthase kinase 3βhippocampalhuman diseasehuman modelhypothalamicimpaired sleepimprovedinherited factorinsightinsoluble aggregateinterestirregular sleepmemapsin 2microtubule associated protein tau aggregationmicrotubule associated protein tau depositmodel of humanmouse modelmurine modelneural inflammationneuroinflammationneuroinflammatoryneuronalneuropathologicneuropathologicalneuropathologynon-drug therapynon-drug treatmentnondrug therapynondrug treatmentp-taup-τpaired helical filament of tauphospho-tauphospho-τphosphorylated taupost-translational modification of tauposttranslational modification of taupre-clinicalpreclinicalprimary degenerative dementiaprotein aggregateprotein aggregationrapid eye movement sleepresolutionsself-aggregate tausenile dementia of the Alzheimer typesleep controlsleep disruptionsleep dysregulationsleep regulationsleep to wake transitionsleep to wakefulness transitionsleep wakefulness cyclesleep/wake disruptionsleep/wake disturbancesleep/wake regulationsleep/wake transitionssocialsoluble amyloid precursor proteinsuprachiasmatic nucleustau PHFtau accumulationtau aggregatetau aggregationtau fibrillizationtau filamenttau neurofibrillary tangletau oligomertau paired helical filamenttau phosphorylationtau polymerizationtau posttranslational modificationtau-1tau-tau interactionvascular dysfunctionvasculopathyβ-secretase 1β-site APP cleaving enzyme 1γ-Aminobutyric Acidτ aggregationτ phosphorylation
Description preview
Disturbances in the sleep–wake cycle and circadian rhythms are common and debilitating symptoms of Alzheimer’s disease (AD), yet effective treatments are lacking. Emerging evidence suggests that physical activity may benefit brain health, but its effects on sleep regulation in AD remain poorly understood. This project investigates the impact of…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click