grant
Pathophysiological mechanisms of cannabidiol in stress regulation
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 May 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY202621+ years oldAcuteAddressAdultAdult HumanAeroseb-HCAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimal ModelAnimal Models and Related StudiesAnimalsAnteriorAnti-Anxiety AgentsAnti-Anxiety DrugsAnxietyAnxiolytic AgentsAnxiolyticsBehaviorBehavioralBioavailabilityBiological AvailabilityBrain regionBuffersCannabidiolCannabinoidsCannabisCardiac ChronotropismCentral LobeCetacortClinicalClinical TrialsConsumptionCornu AmmonisCorpus StriatumCorpus striatum structureCort-DomeCortefCortenemaCortisolCortisprayCortrilCountryCuesDataDependenceDermacortDiagnosticDoseDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrug KineticsDrug TherapyDrugsEarly InterventionEcologic MonitoringEcological MonitoringEldecortEndocrineEnvironmental MonitoringExhibitsFemaleFunctional MRIFunctional Magnetic Resonance ImagingGlnGlutamatesGlutamineH+ elementHeart RateHippocampusHourHumanHydrocortisoneHydrocortoneHydrogen IonsHyperactivityHypothalamic structureHypothalamusHytoneImageImpairmentIndividualInsulaInsula of ReilIsland of ReilL-GlutamateL-GlutamineLaboratoriesLeadLegalMR SpectroscopyMagnetic Resonance SpectroscopyMedicalMedicationMedicineMental disordersMental health disordersMinor Tranquilizing AgentsModalityModern ManMoodsMorbidityN-acetyl aspartateN-acetyl-L-aspartateN-acetylaspartateNerve CellsNerve UnitNeural CellNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurobiologyNeurocyteNeuronsNucleus AccumbensNutracortOralOutcomePathway interactionsPb elementPersonsPharmaceutical PreparationsPharmacokineticsPharmacological TreatmentPharmacotherapyPhenotypePhysiologicPhysiologic AvailabilityPhysiologicalPituitary-Adrenal SystemPlacebo ControlPlacebosPopulationPrefrontal CortexProctocortProtonsPsychiatric DiseasePsychiatric DisorderPsychiatryPsychopathologyQ LevoglutamideQ. LevoglutamideRandomizedRecreationRegulationResearchRestRoleSafetyScanningSex DisordersSexual DysfunctionSham TreatmentSocietiesStimulusStressStriate BodyStriatumSubstance Use DisorderSymptomsSystemTestingTherapeuticTrier Social Stress TestVentral Tegmental AreaVulnerable Populationsabnormal psychologyacute stressadult youthadulthoodamygdaloid nuclear complexbiological adaptation to stresscannabinoid receptorcingulate cortexdesigndesigningdouble-blind placebo control trialdouble-blind placebo controlled trialdouble-masked controlled trialdrug discoverydrug interventiondrug treatmentdrug/agentearly adversityearly childhood adversityearly life adversityenvironmental testingexperiencefMRIflexibilityflexibleglutamatergicheavy metal Pbheavy metal leadhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhippocampalhypothalamicimagingimprovedindexingmalemental illnessmodel of animalmortalityneuralneural imagingneuro-imagingneurobiologicalneurobiological mechanismneuroimagingneurological imagingneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachopiate use disorderopioid use disorderpathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspituitary adrenal axisplacebo controlledpsychiatric illnesspsychological disorderrandomisationrandomizationrandomly assignedreaction; crisisresponsesham therapysocial rolestress reactivitystress related disorderstress responsestress symptomstress; reactionstriatalsubstance use and disordersymptomatologytranslational neuroscienceventral tegmentumvulnerable groupvulnerable individualvulnerable peopleyoung adultyoung adult ageyoung adulthood♀♂
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PROJECT SUMMARY
Dysregulation in stress responsivity, encompassing mesocorticolimbic and hypothalamus-pituitary-adrenal-axis
pathways, is a psychiatry-transdiagnostic fundamental phenomenon. Current anxiolytic pharmacotherapies are limited
in their efficacy and could cause dependence, low tolerance, and sexual dysfunction. With the growing number…
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