grant
Pathogenic Exosomes in COPD
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026A1PIAfrican AmericanAfro AmericanAfroamericanAnimal ModelAnimal Models and Related StudiesAnimalsAntiproteasesAsianBiochemistryBiological ChemistryBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesCOPDCardiologyCaucasianCaucasian RaceCaucasiansCaucasoidCaucasoid RaceCell BodyCell DeathCell-Extracellular MatrixCellsCellular biologyChemistryChronicChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseDNA Molecular BiologyDiseaseDisorderECMEndopeptidase InhibitorsEsteroproteasesExtracellular MatrixExtracellular Matrix DegradationFacultyGoalsGrantGranulocyte ElastaseHumanHuman BiologyImmuneImmunesInflammationLatinaLeukocyte ElastaseLysosomal ElastaseMD studentsMarrow NeutrophilMedical StudentsMentorsMiceMice MammalsMissionModelingModern ManMolecular BiologyMurineMusNHLBINational Heart, Lung, and Blood InstituteNational Institutes of HealthNeutrophil ElastaseNeutrophilic GranulocyteNeutrophilic LeukocyteOccidentalPMN ElastasePathogenicityPathway interactionsPatientsPeptidase InhibitorsPeptidasesPeptide Hydrolase InhibitorsPeptide HydrolasesPeptide Peptidohydrolase InhibitorsPh D studentPh D. studentPh. D. studentPh.D studentPh.D. studentPhD studentPhD. studentPhasePhenotypePhysiciansPhysiologyPolymorphonuclear CellPolymorphonuclear Leukocyte ElastasePolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPostdocPostdoctoral FellowProtease AntagonistsProtease GeneProtease InhibitorProteasesProtein Kinase InteractionProteinase InhibitorsProteinasesProteolytic EnzymesReceptor-Interacting ProteinResearchResearch AssociateResearch ResourcesResistanceResourcesRoleScientistSmokerSmokingStrategic visionSurfaceTissuesTrainingTranslatingUnited States National Institutes of HealthWorkalpha 1 Antiproteasealpha 1-Antiproteinasealpha 1-Antitrypsinalpha 1-Antitrypsin Trypsin Inhibitoralpha 1-Protease Inhibitoralpha 1-Proteinase Inhibitorcell biologychronic inflammatory diseasechronic obstructive pulmonary disordercigarette smoke exposurecigarette smoke-induceddisease phenotypedoctoral studentexosomeexposure to cigarette smokeextracellularextracellular vesicleshuman diseaseinnovateinnovationinnovativemedical school studentsmembermodel of animalmouse modelmultidisciplinarymurine modelnecrocytosisneutrophilnew diagnosticsnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation diagnosticsnext generation therapeuticsnovelnovel diagnosticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathogenpathwaypost-docpost-doctoralpost-doctoral traineeprogramspulmonaryresearch associatesresistantsocial roletherapeutic agent developmenttherapeutic developmentwhite raceα1-Antitrypsinα1-Proteinase Inhibitor
Description preview
PROJECT SUMMARY
The thesis of this R35 Program is that immune cell derived “pathogenic exosomes” are
key players in chronic obstructive pulmonary disease (COPD) and that their role can be
modeled in a smoking mouse model of exosome transfer to attain novel understanding of the
disease which can in turn be applied to COPD. This R35 Program is at…
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