grant
Pathogenic exosomes during herpes zoster mediate increased vascular dementia risk
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 20 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025(TNF)-α19S Gamma Globulin3-10C7S Gamma GlobulinAC GlobulinAMCF-IAPOE e4APOE-ε4APOEε4AccelerationActivated Partial Thromboplastin TimeActivated Partial Thromboplastin Time measurementActive OxygenAcuteAdhesionsAge YearsAgingAmentiaAmericanAmyloidAmyloid SubstanceAngiitisAnti-viral AgentsAnti-viral TherapyAntiplatelet AgentsAntiplatelet DrugsApoplexyArteriosclerotic DementiaAssayB cell differentiation factorB cell growth factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-1B-Cell Differentiation Factor-2B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-Cell Stimulatory Factor-2BCDFBCDF-1BCGFBCGF-1BCSF 1BSF-1BSF-2BSF1BSF2Beta Proprotein Interleukin 1BinetrakinBioassayBioinformaticsBiologicalBiological AssayBiologyBlood Coagulation Factor VBlood PlasmaBlood PlateletsBlood VesselsBlood flowBlood leukocyteBrain VascularBrain Vascular AccidentBrain Vascular DisordersBrain hemorrhageBrain regionCALM2CAM1CD62P AntigensCSIFCSIF-10CXCL8CachectinCalmodulin 1CaveolaeCaveolasCell BodyCellsCerebral StrokeCerebral ThrombosisCerebrovascular ApoplexyCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeChickenpox VirusClinic VisitsClinicalClinical ResearchClinical StudyClot retractionCo-StimulatorCoagulation Factor VCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplete Blood CountCostimulatorCytokine Synthesis Inhibitory FactorDNA VirusesDataDegenerative Neurologic DisordersDementiaDevelopmentDiabetes MellitusDiameterDiseaseDisorderDistalDisturbance in cognitionEnsureEnvironmental FactorEnvironmental Risk FactorEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEpidermal Thymocyte Activating FactorEventExanthemExanthemaFactor PiFactor VFibroblastsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGCP1GMP-140GenerationsHHV-3HHV3HPGFHepatocyte-Stimulating FactorHerpes ZosterHerpes zoster VirusHerpes zoster diseaseHerpesvirus Type 3Herpesvirus varicellaeHost FactorHost Factor ProteinHumanHybridoma Growth FactorHyperlipemiaHyperlipidemiaHypertensionIFN-GammaIFN-beta 2IFN-gIFN-γIFNB2IFNGIFNγIL-1 betaIL-1 βIL-1-bIL-10IL-13IL-1βIL-2IL-4IL-6IL-8IL1-BetaIL1-βIL10IL10AIL13IL1B ProteinIL1F2IL1βIL2 ProteinIL4 ProteinIL6 ProteinIL8IL8 geneIgGIgMImmune InterferonImmunoglobulin GImmunoglobulin MImpaired cognitionIndividualInfectionInflammationInflammatoryIntegration Host FactorsInterferon GammaInterferon Type IIInterleukin 10 PrecursorInterleukin 1betaInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-1 betaInterleukin-10Interleukin-13Interleukin-1βInterleukin-2Interleukin-4Interleukin-4 PrecursorInterleukin-6Interleukine 2Interleukine 2 PrecursorInterleukine IIIntracranial Vascular DiseasesIntracranial Vascular DisordersInvestigatorsIschemic StrokeK60LECAM-3LaboratoriesLeukocytesLeukocytes Reticuloendothelial SystemLymphocyte Mitogenic FactorLymphocyte Stimulatory Factor 1MCGF-2MGI-2Macrophage-Derived TNFMarrow leukocyteMarrow plateletMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMast Cell Growth Factor-2MediatingMetabolicMicroRNAsMicrofluidicsMitogenic FactorModelingModern ManMonocyte-Derived TNFMyeloid Differentiation-Inducing ProteinNatureNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologyNeuron DegenerationOccluding JunctionsOcular Herpes zoster VirusOxygen RadicalsP-SelectinPartial Thromboplastin TimePathogenesisPathogenicityPathologyPathway interactionsPatientsPhosphatidylserinesPlasmaPlasma SerumPlasmacytoma Growth FactorPlatelet ActivationPlatelet alpha-Granule Membrane ProteinPlateletsPrealbuminPreinterleukin 1 BetaPro-OxidantsProaccelerinProalbuminProcessProteinsRNA SeqRNA sequencingRNAseqRashReactive Oxygen SpeciesResearchResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRisk ReductionRisk-associated variantSCYB8SamplingSerine PhosphoglyceridesShinglesSiteSkin RashSmall RNAStrokeT cell growth factorT-Cell Growth FactorT-Cell Growth Factor 2T-Cell Stimulating FactorTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTSG-1TSP-1TSP1TestingTherapeuticThrombocytesThrombosisThrombospondin 1Thymocyte Stimulating FactorTight JunctionsTransthyretinTumor Necrosis FactorTumor Necrosis Factor-alphaUpregulationVZ VirusVZV vasculopathyVaccinationVaccinesVaricella-Zoster VirusVascular DementiaVascular DiseasesVascular DisorderVascular Endothelial CellVascular Hypertensive DiseaseVascular Hypertensive DisorderVasculitisViral DiseasesViremiaVirus ActivationVirus DiseasesVirus InductionWhite Blood CellsWhite CellZonaZonula OccludensZosterZoster VaccineaPTTanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4b-ENAPbiobankbiologicbiorepositorybleeding in brainblood vessel disorderbrain attackbrain vascular diseasebrain vascular dysfunctioncerebral arterycerebral vascularcerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebro-vascularcerebrovascularcerebrovascular accidentcerebrovascular contributions to dementiacerebrovascular dysfunctionclinical centerclinical practicecognitive dysfunctioncognitive losscytokinedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdementia riskdevelopmentaldiabetesenvironmental riskepidemiologic investigationepidemiology studyexosomeexperimentexperimental researchexperimental studyexperimentsextracellular vesiclesflow cytophotometryhemorrhagic strokeherpes zonahigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderinterferon beta 2intracranial vascular dysfunctionknock-downknockdownlFN-Gammalabile componentlabile factormalleable riskmiRNAmodifiable riskneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationneurotropicpathogenpathwayplatelet functionpreventpreventingreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrisk allelerisk factor for dementiarisk for dementiarisk generisk genotyperisk locirisk locusrisk variantrisk-reducingstrokedstrokesthrombotic diseasethrombotic disordertranscriptome sequencingtranscriptomic sequencingvaricella zoster virus vasculopathyvascularvascular contributions in dementiavascular contributions to dementiavascular dysfunctionvascular related dementiavasculitidesvasculopathyviraemiaviral activationviral inductionviral infectionviral infectious disease treatmentviral sepsisvirus infectionvirus-induced diseasevirusemiawhite blood cellwhite blood corpuscleµfluidic
Description preview
Project Summary: Vascular dementia is the second most common cause of dementia. Therapies aim to
control risk factors (e.g. hypertension, hyperlipidemia, and diabetes mellitus) to prevent development or
worsening of disease. Recent studies show that viral infections are potentially modifiable risk factors for
dementia. Amongst all pathogens,…
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