grant
Pathogenesis of Tick-Borne Flavivirus Infections
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAllergic ReactionAnatomic SitesAnatomic structuresAnatomyAnimal HospitalsAnimal ModelAnimal Models and Related StudiesAnimalsAnti-viral AgentsAreaArgasArthropodaArthropodsArtificial FeedingArtificial MembranesAssayAttenuatedAvesAvianB burgdorferiB. burgdorferiBacteriaBasic ResearchBasic ScienceBehaviorBehavioralBioassayBiological AssayBiologyBirdsBiteBlack-legged TickBody TissuesBorreliaBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorreliella burgdorferiCaliforniaCell BodyCell Culture TechniquesCell LineCell membraneCellLineCellsCellular biologyCessation of lifeCollaborationsCollectionCommunity OutreachComparative Genomic AnalysisCountyCoxiellaCytoplasmCytoplasmic MembraneDNA Molecular BiologyDataDeathDeerDeer TickDevelopmentDiseaseDisease VectorsDisorderDissociationDomestic FowlsEcdysisElementsEmbryoEmbryonicEndoplasmic ReticulumEntomologyErgastoplasmEvolutionExperimental ModelsFamilyFarm AnimalFeeding MethodsFeeding behaviorsFlavivirusFlavivirus InfectionsGene ExpressionGene TranscriptionGenesGenetic TranscriptionGenomeGenomicsGeographyGoalsGroup B ArbovirusGullHealth Care ProfessionalHealth ProfessionalHistologicHistologicallyHistologyHospitalsHumanI scapularisI. scapularisImageImaging ProceduresImaging TechnicsImaging TechniquesImmunologyIn Situ HybridizationIndigenousIndividualInfectionIngestive BehaviorIslandIx scalpularisIx. scapularisIxodes damminiIxodes scapularisIxodidaKidneyKidney Urinary SystemLaboratoriesLaboratory StudyLaridaeLarvaLibrariesLivestockLocationLong-term infectionLyme BorreliosisLyme DiseaseLyme Disease SpirocheteMaintenanceMammaliaMammalsMapsMedicalMethodsMicrobeMidgutModelingModern ManMolecularMolecular BiologyMoltingMontanaMorphologyMotilityNatureNon-Polyadenylated RNANorth DakotaNymphOrganOrthoflavivirusPathogenesisPathogenicityPersonsPlasma MembranePoultryPowassanPowassan virusProceduresProcessProteomicsProtocolProtocols documentationPublic HealthPublicationsPublishingRNARNA ExpressionRNA Gene ProductsReportingReproducibilityResearchResearch SpecimenRibonucleic AcidRiskSalivary GlandsSamplingScanning Electron MicroscopyScientific PublicationSecureSingle cell seqSortingSpecimenStrains Cell LinesSystemTestingTick-Borne DiseasesTicksTimeTissuesTranscriptionTransfectionTransmissionTurtlesUnited StatesUniversitiesVeterinary ClinicsVeterinary HospitalsViralViral BurdenViral DiseasesViral LoadViral Load resultViral reservoirVirusVirus DiseasesVirus ReplicationVirus reservoirWorkacute infectionadulthoodanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsattenuateattenuatesbacteria pathogenbacterial pathogenblacklegged tickborrelialcell biologycell culturecell cultureschronic infectioncohortcollegecollegiatecompanion animalcompanion petcomparativecultured cell linedevelopmentalemerging pathogenendosymbiontexperimentexperimental groupexperimental researchexperimental studyexperimentsfeedingfeeding-related behaviorsglobal gene expressionglobal transcription profilehuman pathogenimagingimprovedin situ Hybridization Geneticsin situ Hybridization Staining Methodinfection rateinsightlyme spirochetemicrobiomemodel of animalnew pathogennovelnovel pathogennutrient intake activityoutreach programpathogenpathogenic bacteriapersistent infectionplasmalemmaplasmid DNAprogramsprotein distributionrate of infectionrenalreverse geneticssingle cell analysissingle cell next generation sequencingsingle cell sequencingsingle cell technologytick blood feedingtick blood mealtick bloodmealtick fedtick feedingtick imbibestick-bornetick-borne flavivirustick-borne illnesstick-borne virustickbornetickborne diseasetickborne flavivirustickborne illnesstickborne virustortoisetranscriptometransmission processvectorvector tickvector transmissionvector-bornevectorborneviral infectionviral multiplicationviral replicationvirologyvirus infectionvirus multiplicationvirus-induced disease
Description preview
Research in our laboratory employs virology, immunology, entomology, advanced imaging techniques, genomics, proteomics, cell biology, molecular biology, and vector biology. We primarily study LGTV at BSL2 and POWV/DTV at BSL3.
TBFV biology in I. scapularis.
Infection in ticks is a critical, but understudied, feature of TBFV biology. Ticks are…
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