grant
Pathogenesis and Treatment of Anaphylaxis
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Active Follow-upAdverse reactionsAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAntigensBasophilic GranulocyteBasophilsBlood BasophilC-KIT GeneCD117CD117 AntigensClinicalCollaborationsDNA mutationDataData CollectionDiagnosisDifferential DiagnosisDiseaseDisorderDrug AllergyDrug HypersensitivityDrugsEuropeanFoodGenetic ChangeGenetic defectGenetic mutationHereditaryHigh PrevalenceIdiopathic anaphylaxisImmune mediated therapyImmunologically Directed TherapyImmunotherapyInheritedInsect StingInvestigationMalignant MastocytosisManuscriptsMarrow Mast CellMast Cell Growth Factor ReceptorMast-Cell DiseaseMeat HypersensitivityMediatorMedicationModelingMorbidityMorbidity - disease rateMutationPathogenesisPatientsPharmaceutical PreparationsPrevalenceProbabilityProspective StudiesProteomicsProto-Oncogene Protein c-kitProtocolProtocols documentationReactionRecurrenceRecurrentReportingResearchRiskSCF ReceptorSCF Receptor GeneSCFRSafetySeveritiesStem Cell Factor ReceptorStem Cell Factor Receptor GeneSyndromeSystemic Mast-Cell DiseaseSystemic MastocytosisSystemic Tissue Mast Cell DiseaseTissue BasophilsVenomsactive followupallergic to meatallergy to meatalpha-gal allergicalpha-gal allergyalpha-gal syndromeanaphylactic response to foodanaphylaxis caused by foodanaphylaxis due to foodanaphylaxis to foodbiomarker identificationc kitc-kit Proteinc-kit Receptorcareercofactorcohortcomputer based predictiondrug/agentexperiencefollow upfollow-upfollowed upfollowupfood allergy anaphylaxisfood anaphylactic reactionfood anaphylaxisfood associated anaphylaxisfood induced anaphylaxisfood mediated anaphylaxisfood related anaphylaxisfood triggered anaphylaxisgenome mutationidentification of biomarkersidentification of new biomarkersimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenkit Proto-Oncogene Proteinmarker identificationmast cellmast cell hyperplasiamaster's coursesmaster's educationmaster's programmastocytemastocytosismeat allergymortalityp145(c-kit)p145c-kitparticipant enrollmentpatient enrollmentpatient populationpharmacologicpredictive modelingprospectiveα-gal allergicα-gal allergyα-gal syndrome
Description preview
We have evaluated 116 patients referred for idiopathic anaphylaxis (IA) and antigen-specific anaphylaxis (SA) to explore pathogenesis and identify patients with clonal mast cell disease. Overall, 29% have been diagnosed with a clonal mast cell disease, 19.5% with a primary diagnosis of IA. Of the patients with SA, 54% with a primary diagnosis of…
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