grant

Pathogen and patient determinants of Candida gut colonization in critically ill patients

Organization METHODIST HOSPITAL RESEARCH INSTITUTELocation HOUSTON, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years oldAccelerationAdultAdult HumanAffectAntibiotic AgentsAntibiotic DrugsAntibioticsAssayAwardBacterial InfectionsBioassayBiological AssayBlood CirculationBlood PlasmaBloodstreamC albicansC aurisC. albicansC. aurisC. glabrataC.albicansCandidaCandida albicansCandida aurisCandida glabrataCandida resistanceCandida resistant isolateCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCathetersCharacteristicsChromosome MappingClinicalClinical ResearchClinical StudyCommunicable DiseasesComparative Genomic AnalysisCoupledCritical CareCritical IllnessCritically IllDataData AnalysesData AnalysisData CollectionData ScienceDedicationsDefectDevelopmentDoctor of PhilosophyEnsureFundingFungal Drug ResistanceFungus drug resistantGI colonizationGene LocalizationGene MappingGene Mapping GeneticsGeneticGenetic DeterminismGenetic DiversityGenetic VariationGenomicsGoalsHospitalsHybridsIFNImmuneImmune responseImmunesImmunityImmunologic FactorsImmunological FactorsImpairmentInfectionInfectious DiseasesInfectious DisorderInstitutionIntensive Care UnitsInterferonsIntestinalIntestinesInvadedK-AwardsK-Series Research Career ProgramsLifeLinkLinkage MappingLogistic RegressionsMedical centerMentorsMentorshipMethodist ChurchMethodistsMinorityMiscellaneous AntibioticModelingMoniliaMorbidityMorbidity - disease rateMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantNational Institutes of HealthOutcomePathogenesisPathologyPatient CarePatient Care DeliveryPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPh.D.PhDPhenotypePhysiciansPlasmaPlasma SerumPopulationPredisposing FactorPredispositionPrevalenceProductionResearchResearch Career ProgramResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant candidaResistant to Multiple DrugResistant to multi-drugResistant to multidrugReticuloendothelial System, Serum, PlasmaRisk FactorsScientistSiteSkin colonizationSusceptibilityT cell responseT-CellsT-LymphocyteTestingTexasTorulopsis glabrataTotal Human and Non-Human Gene MappingTrainingTranslational ResearchTranslational ScienceUnited States National Institutes of HealthVenousadulthoodadverse consequenceadverse outcomeanti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantbacteria infectionbacterial diseaseblood infectionbloodstream infectionbowelcandidaemiacandidemiacare for patientscare of patientscareercaring for patientsclinical riskcohortcytokinedata interpretationdesigndesigningdevelopmentalentire genomefecal samplefull genomefungal pathogenfungi pathogenfungus drug resistancegastrointestinalgastrointestinal tract colonizationgenetic determinantgenetic mappinggenome sequencinggenomic epidemiologygut colonizationhigh riskhost responseimmune system responseimmunologic substanceimmunological substanceimmunoresponseimprovedinfection in the bloodinfection of the bloodinsightintestinal colonizationmicrobial genomicsmortalitymulti-drug resistantmultidrug resistantnovelpathogenpathogenic funguspatient oriented outcomespatient oriented researchpatient oriented studypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentresistance among Candidaresistance generesistance in Candidaresistance locusresistance to anti-fungalresistant Candida strainsresistant generesistant to anti-fungalresponsesample collectionspecimen collectionstool samplestool specimenthymus derived lymphocytetraittranslation researchtranslational investigationtreatment strategytrendurgent and serious threaturgent or serious threatwhole genome
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PROJECT SUMMARY/ABSTRACT
This K23 proposal outlines a five-year research and training plan that will accelerate Dr. Max Adelman's career

as an independent physician-scientist with expertise in Candida colonization and infection in critically ill

patients. Dr. Adelman is an infectious diseases and critical care clinician whose translational…

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