grant
Parkin tumor suppression
Organization WISTAR INSTITUTELocation PHILADELPHIA, UNITED STATESPosted 5 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025APF-1ATP-Dependent Proteolysis Factor 1Antitumor ResponseAreaAutophagocytosisBiochemicalBody TissuesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCell Communication and SignalingCell DeathCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular Metabolic ProcessCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessClinicCollaborationsComplexConsensusDataDedicationsDendritic CellsDiseaseDisease ProgressionDisorderE3 LigaseE3 Ubiquitin LigaseER stressEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumFeedbackGene ExpressionGene TranscriptionGenesGenetic TranscriptionHMG-20Hexose Monophosphate ShuntHigh Mobility Protein 20HumanIFNIFN activationImmuneImmune mediated therapyImmunesImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyInfiltrationInflammasomeInflammatoryInnate ImmunityInterferon ActivationInterferonsIntermediary MetabolismInternationalIntracellular Communication and SignalingInvestigationKinasesLaboratoriesLettersMacromolecular Protein ComplexesMalignant NeoplasmsMalignant TumorMapsMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMitochondriaModern ManMolecularMolecular Tumor SuppressionMultiprotein ComplexesMyelogenousMyeloidNative ImmunityNatural ImmunityNeoplasm MetastasisNon-Specific ImmunityNonspecific ImmunityOrganellesOxidation-ReductionParalysis AgitansParkinParkin geneParkinsonParkinson DiseasePathway interactionsPatientsPatternPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPhosphotransferase GenePhosphotransferasesPrimary NeoplasmPrimary ParkinsonismPrimary TumorProductionRNA ExpressionRedoxRegulationRoleSTAT1STAT1 geneSTAT91ScienceSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSortingStimulator of Interferon GenesSubcellular ProcessT-Cell ActivationT8 CellsT8 LymphocytesTestingTissuesTranscriptionTranscription ActivationTranscriptional ActivationTransgenic MiceTransgenic ModelTransphosphorylasesTumor SuppressionTumor Suppressor ProteinsUbiquitinUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3Veiled CellsViral DiseasesVirusVirus Diseasesactivate T cellsadvanced diseaseadvanced illnessanti-tumor responseautophagybalancebalance functionbiological adaptation to stressbiological signal transductioncGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcancer immunologycancer metastasiscancer vaccinationcell metabolismcell motilitycellular metabaolismconventional therapyconventional treatmentcyclic GMP-AMP synthase/STINGcytokineearly onsetendoplasmic reticulum stressenergy efficiencyepigeneticallyextracellulargenetic make-upgenetic makeupimmune microenvironmentimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmunization strategyimmuno therapyimmunogenic apoptosisimmunogenic cell deathimmunosuppressive activityimmunosuppressive functionimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentimprovedin vivomalignancymitochondrialmouse modelmultidisciplinarymurine modelnecrocytosisneoplasm immunologyneoplasm/cancernew approachesnovelnovel approachesnovel strategiesnovel strategyoxidation reduction reactionparkin proteinpathwaypatient responsepatient specific responsepre-clinicalpreclinicalprogramsprotein complexreaction; crisisrecruitresponseresponsive patientsocial rolestress bufferingstress managementstress responsestress; reactiontherapeutic targettraffickingtraittransgenic traittumortumor cell metastasistumor growthtumor immune microenvironmenttumor immunologytumor suppressortumor vaccinationtumor-immune system interactionsubiquitin-protein ligasevaccination strategyviral infectionvirus infectionvirus-induced disease
Description preview
PROJECT SUMMARY
The loss of endogenous tumor suppressors is an obligatory step in tumor onset and progression, but the
underlying mechanisms are elusive and the breadth of their targets mostly unknown. We have now discovered
that Parkin, a mitochondria-associated E3 ubiquitin ligase biallelically altered in early-onset Parkinson’s
Disease,…
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