grant
Paraventricular Nucleus of the Thalamus and Nucleus Accumbens Neurons in Aversion-Resistant Alcohol Drinking
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 31 Jan 2026Deadline 30 Jan 2028
NIHUS FederalResearch GrantFY2025AffectAffectiveAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAppetiteAutomobile DrivingBehaviorBrain regionCell Communication and SignalingCell SignalingChronic DiseaseChronic IllnessCommon Rat StrainsConflictConflict (Psychology)CuesDataDesire for foodDevelopmentDiseaseDisorderDopamineDrug InteractionsDrugsElectrophysiologyElectrophysiology (science)EmotionsEnvironmentEtOH drinkingEtOH useFemaleGlutamatesGoalsGustationHumanHydroxytyramineIntracellular Communication and SignalingIpsilateralKnowledgeL-GlutamateLearningLocationLong-Evans RatsMeasuresMediatingMedicationMiceMice MammalsMinnesotaModern ManMotivationMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeurosciencesNucleus AccumbensOutcomeParaventricular Nucleus of ThalamusParaventricular Thalamic NucleusPathway interactionsPharmaceutical PreparationsPhasePopulationPredispositionPreventionProcessQuinineRatRats MammalsRattusResearchResearch EthicsResearch TechnicsResearch TechniquesResistanceRewardsRoleSaccharoseScientistSelf AdministeredSelf AdministrationSignal TransductionSignal Transduction SystemsSignalingSourceStimulusStructure of paraventricular nucleus of thalamusSucroseSusceptibilitySynaptic plasticityTasteTaste PerceptionTechniquesTimeTrainingUniversitiesWorkaccess to alcoholaddictionaddictive disorderalcohol abuse therapyalcohol abuse treatmentalcohol accessalcohol accessibilityalcohol availabilityalcohol cuealcohol ingestionalcohol intakealcohol product usealcohol related cuealcohol related researchalcohol researchalcohol rewardalcohol treatmentalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeawakebiological signal transductioncareerchronic disorderdevelopmentaldrinkingdrivingdrug/agentelectrophysiologicalethanol accessibilityethanol availabilityethanol consumptionethanol cueethanol drinkingethanol ingestionethanol intakeethanol product useethanol researchethanol rewardethanol useethanol use disorderexperienceglutamatergicgustatory perceptiongustatory processinggustatory responseimprovedin vivomaleneuralneural circuitneural circuitryneural mechanismneurocircuitryneuromechanismneuronaloptogeneticspathwaypharmacologicpreventpreventingresistantskillssocial rolesynaptic circuitsynaptic circuitrytaste processingtaste response♀♂
Description preview
Project Summary/Abstract
This project proposes to investigate the underlying neural mechanisms within the nucleus accumbens (NAc)
driving cue-elicited reward seeking during aversion-resistant alcohol drinking (ARD), defined as drinking
despite negative consequences or “compulsive alcohol drinking”, using optogenetics and simultaneous in-vivo…
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