grant
Paramyxoviruses as Vaccine Vectors Against Highly Pathogenic Viruses
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old21+ years old7S Gamma GlobulinAdultAdult HumanAdverse ExperienceAdverse eventAerosolsAlpha VirusAnimal ExperimentsAnimalsAntibodiesAntibody ResponseAntibody titer measurementAntigensAssayAttenuatedAvian Influenza A VirusAvian Influenza VirusAvian Orthomyxovirus Type AAvian Paramyxovirus 1Avian ParamyxovirusesAvulavirusBioassayBiological AssayBlood SerumBovine SpeciesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCDC42 Homolog GeneCDC42-Interacting Protein GeneCIP4CattleCaviaCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCell Surface AntigensCell Surface GlycoproteinsCellsChildChild YouthChildren (0-21)ChimeraChimera organismClinicalClinical ResearchClinical StudyCytoplasmData AnalysesData AnalysisDevelopmentDoseEBOVEBOV GPEarly-Stage Clinical TrialsEbola virusEbola virus GP gene productEbola virus envelope glycoproteinEbola-like VirusesEffectivenessEngineeringFamily memberFowl Plague VirusFutureG25K GeneGP Ebola virusGP GeneGene ArrangementGene OrderGene PositionGene TranscriptionGenerationsGenesGenetic TranscriptionGenomeGenomicsGlycoproteinsGroup A ArbovirusesGuinea PigsGuinea Pigs MammalsHPIV1HPIV3Helper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHemadsorption Type 2 VirusHemadsorption Virus 1Hemadsorption Virus 2HumanHuman Parainfluenza Virus 1Human Parainfluenza Virus 3IgAIgGImmune responseImmunityImmunoglobulin AImmunoglobulin GImmunological Surface MarkersInducer CellsInducer T-LymphocytesInfantInfectionInfluenza HAInfluenza HemagglutininInpatientsIntracellular Communication and SignalingIntranasal AdministrationIntranasal Drug AdministrationLungLung Respiratory SystemM mulattaM. mulattaMacacaMacaca mulattaMacaca rhesusMacaqueMeasuresMediatingMembrane GlycoproteinsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMessenger RNAMiceMice MammalsModern ManModificationMucosaMucosal ImmunityMucosal TissueMucous MembraneMurineMurine pneumonia virusMusMyxovirus pestis galliNasal Lavage FluidNasal WashingNasal WashingsNational Institutes of HealthNewcastle disease virusNon-Polyadenylated RNAOrthoebolavirusOrthopneumovirusPara-Influenza Virus Type 1Para-Influenza Virus Type 3ParamyxoviridaeParamyxovirusParticipantPathogenicityPhase 1 Clinical TrialsPhase I Clinical TrialsPhase I StudyPlacebosPneumonia Virus of MicePneumoviridaePneumovirinaePneumovirusPolymerasePopulationPreparationPrimatesPrimates MammalsProteinsPublic Health SchoolsPublicationsPulmonary Body SystemPulmonary Organ SystemQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNARNA ExpressionRNA Gene ProductsRandomizedRespiratory EpitheliumRespiratory SystemRespiratory TractsRespiratory infectious agentRespiratory syncytial virusRespiratory tract pathogenRespiratory tract structureRhesus MacaqueRhesus MonkeyRibonucleic AcidRodentRodentiaRodents MammalsRouteSARS VirusSARS corona virusSARS coronavirusSARS-Associated CoronavirusSARS-CoVSARS-CoV-1SARS-Related CoronavirusSafetySamplingScientific PublicationSerumSevere Acute Respiratory CoronavirusSevere Acute Respiratory Syndrome VirusSevere Acute Respiratory Syndrome corona virusSevere Acute Respiratory Syndrome coronavirusSham TreatmentSignal TransductionSignal Transduction SystemsSignalingStructure of respiratory epitheliumSurface AntigensSurface GlycoproteinsSurface ProteinsSystemT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTRIP10TRIP10 geneTestingThyroid Hormone Receptor Interactor 10 GeneTimeTranscriptionUnited States National Institutes of HealthUpper respiratory tractVaccinationVaccinesViralViral SheddingViral VaccinesVirionVirusVirus ParticleVirus ReplicationVirus SheddingWorkadulthoodairway epitheliumanimal experimentantibody titeringantigen based testantigen testattenuateattenuatesattenuationavian flu virusavian paramyxovirus serotype 1biological signal transductionbird flu virusbovidbovinecell culturecell cultureschimerascohortcowdata interpretationdeliver vaccinesdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalemerging pathogenexperimental animalexperimental animalsexpression vectorflu HAflu hemagglutininhost responseimmune system responseimmunogenimmunogenicimmunogenicityimmunoresponseinfluenza viral HAinfluenza viral hemagglutinininfluenza virus HAinfluenza virus hemagglutininkidsmRNAneutralizing antibodynew pathogennon-human primatenonhuman primatenovel pathogenopen labelopen label studyparainfluenza virusparainfluenza virus type 1parainfluenza virus type 3pathogenpathogenic virusphase 1 studyphase I protocolplasmid vaccinepreparationsqRTPCRrandomisationrandomizationrandomly assignedrespiratoryrespiratory pathogenrespiratory tract epitheliumresponsereverse geneticssafety studyseropositivesevere acute respiratory syndrome-CoVsham therapytissue tropismupper airway tractvaccine candidatevaccine deliveryvaccine developmentvectorvector vaccinevector-based vaccineviral detectionviral multiplicationviral pathogenviral replicationvirus detectionvirus multiplicationvirus pathogenvolunteeryoungster
Description preview
We previously constructed a first-generation construct called HPIV3-EbovZ GP, in which the complete genome of the JS strain of HPIV3 was modified by the addition of the Ebov GP gene in the third gene position, between the HPIV3 P and M genes. The JS strain is thought to be an attenuated HPIV3, based on previous clinical studies, although the basis…
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